Gene Symbol | SLC38A4 |
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Entrez Gene | 55089 |
Alt Symbol | ATA3, NAT3, PAAT, SNAT4 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 38, member 4 |
Other Description | N amino acid transporter 3|Na(+)-coupled neutral amino acid transporter 4|amino acid transporter A3|amino acid transporter system A3|sodium-coupled neutral amino acid transporter 4|system A amino acid transporter 3|system N amino acid transporter 3 |
Swissprots | A8K553 Q969I6 |
Accessions | CAD20438 EAW57917 EAW57918 EAW57919 EAW57920 Q969I6 AB055003 BAB84090 AF193836 AAK71508 AF305814 AAK43528 AK001053 BAA91481 AK291168 BAF83857 BC069819 AAH69819 BC101827 AAI01828 BC104913 AAI04914 CB164010 DB139964 XM_005268997 XP_005269054 NM_001143824 NP_001137296 NM_018018 NP_060488 |
Function | Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}; Multi-pass membrane protein {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}. |
Tissue Specificity | Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels. {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}. |
SNAT4 CRISPR/Cas9 KO Plasmid (h) - sc-412441 from Santa Cruz Biotechnology
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SNAT4 HDR Plasmid (h) - sc-412441-HDR from Santa Cruz Biotechnology
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SNAT4 Double Nickase Plasmid (h) - sc-412441-NIC from Santa Cruz Biotechnology
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SNAT4 Double Nickase Plasmid (h2) - sc-412441-NIC-2 from Santa Cruz Biotechnology
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SNAT4 CRISPR Activation Plasmid (h) - sc-412441-ACT from Santa Cruz Biotechnology
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SNAT4 CRISPR Activation Plasmid (h2) - sc-412441-ACT-2 from Santa Cruz Biotechnology
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SNAT4 Lentiviral Activation Particles (h) - sc-412441-LAC from Santa Cruz Biotechnology
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SNAT4 Lentiviral Activation Particles (h2) - sc-412441-LAC-2 from Santa Cruz Biotechnology
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SNAT4 siRNA (h) - sc-44994 from Santa Cruz Biotechnology
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SNAT4 shRNA Plasmid (h) - sc-44994-SH from Santa Cruz Biotechnology
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SNAT4 shRNA (h) Lentiviral Particles - sc-44994-V from Santa Cruz Biotechnology
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SLC38A4 RNAi - H00055089-R01 from Novus Biologicals
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MISSION® esiRNA - EHU146361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19608 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19608 from Sigma-Aldrich
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SLC38A4 siRNA (Human) - CRJ0459 from Cohesion Biosciences
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SLC38A4 - MBS8233072 from MyBioSource
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SLC38A4 shRNA Plasmid (Human) - CHJ0459 from Cohesion Biosciences
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SLC38A4 miRNA 3'UTR clone - MiUTR3H-09709 from Creative biogene
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SLC38A4 miRNA 3'UTR clone - MiUTR3H-09710 from Creative biogene
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