| Gene Symbol | SNX3 |
|---|---|
| Entrez Gene | 8724 |
| Alt Symbol | Grd19, MCOPS8, SDP3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sorting nexin 3 |
| Other Description | sorting nexin 3A|sorting nexin-3 |
| Swissprots | Q9C0J5 Q5JXJ7 E1P5E5 Q5JXJ8 Q96AP9 A8K0B1 E1P5E4 Q4TT31 Q9NU45 O60493 Q4TT29 O60718 |
| Accessions | EAW48378 EAW48379 EAW48380 EAW48381 EAW48382 EAW48383 EAW48384 O60493 AB047360 BAB32649 AF034546 AAC16040 AF062483 AAC16018 AI921483 AK289476 BAF82165 AV704272 BC008444 AAH08444 BC014580 AAH14580 BC015179 AAH15179 BC016863 AAH16863 BG497532 BQ432490 BT007114 AAP35778 CA442762 CN422502 CR456898 CAG33179 DB502691 EU831975 ACE87416 EU832068 ACE86730 HY023148 HY156437 NM_001300928 NP_001287857 NM_001300929 NP_001287858 NM_003795 NP_003786 NM_152827 NP_690040 NM_152828 |
| Function | Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMe |
| Subcellular Location | Early endosome {ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:21725319}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:23237080}. Note=Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer- decorated non-branched endosomal tubule structures (PubMed:21725319) Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (PubMed:23237080). In the case of Salmonella enterica infection localizes to Salmonella-containing vacuoles (SCVs) from which SNX3-containing tubules form 30-60 min after infection (PubMed:20482551). {ECO:0000269|PubMed:20482551, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080}. |