SNX3

Gene Symbol	SNX3
Entrez Gene	8724
Alt Symbol	Grd19, MCOPS8, SDP3
Species	Human
Gene Type	protein-coding
Description	sorting nexin 3
Other Description	sorting nexin 3A|sorting nexin-3
Swissprots	Q9C0J5 Q5JXJ7 E1P5E5 Q5JXJ8 Q96AP9 A8K0B1 E1P5E4 Q4TT31 Q9NU45 O60493 Q4TT29 O60718
Accessions	EAW48378 EAW48379 EAW48380 EAW48381 EAW48382 EAW48383 EAW48384 O60493 AB047360 BAB32649 AF034546 AAC16040 AF062483 AAC16018 AI921483 AK289476 BAF82165 AV704272 BC008444 AAH08444 BC014580 AAH14580 BC015179 AAH15179 BC016863 AAH16863 BG497532 BQ432490 BT007114 AAP35778 CA442762 CN422502 CR456898 CAG33179 DB502691 EU831975 ACE87416 EU832068 ACE86730 HY023148 HY156437 NM_001300928 NP_001287857 NM_001300929 NP_001287858 NM_003795 NP_003786 NM_152827 NP_690040 NM_152828
Function	Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMe
Subcellular Location	Early endosome {ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:21725319}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:23237080}. Note=Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer- decorated non-branched endosomal tubule structures (PubMed:21725319) Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (PubMed:23237080). In the case of Salmonella enterica infection localizes to Salmonella-containing vacuoles (SCVs) from which SNX3-containing tubules form 30-60 min after infection (PubMed:20482551). {ECO:0000269|PubMed:20482551, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SNX3 full length protein - ab109970 from Abcam Category Protein Source E. coli Species Human

SNX3 Antibody Blocking Peptide - LS-E5912 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNX3 Recombinant Protein - H00008724-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SNX3 Protein - NBP1-72347 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

SNX3-Antibody-Center-Blocking-Peptide - BP18477c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Sorting nexin-3 (OPCA00381) - OPCA00381 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

SNX3 Protein (OPPA00199) - OPPA00199 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human SNX3 protein - orb245074 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human SNX3 protein - orb169334 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E. coli Species Human

SNX3 protein (His tag) - 80R-1860 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

SNX3 Blocking Peptide - abx063509 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Rabbit

Sorting nexin-3 (SNX3) (1-162, His-tag) - AR39041PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Sorting nexin-3 (SNX3) (1-162, His-tag) - AR39041PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Sorting nexin-3 (SNX3) - H00008724-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Sorting nexin-3 (SNX3) - H00008724-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Sorting Nexin 3, Human Recombinant - 228-13000-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Sorting Nexin 3 - 228-13000-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Sorting Nexin 3 - 228-13000-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

SNX3, 1-162aa, Human, His tag, E.coli - 01-2164-3 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

SNX3 fusion protein - ag1160 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SNX3 Human - PRPS-253 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human SNX3 Protein - BP002253-PRO-246 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

SNX3, 1-162aa, Recombinant Protein - GWB-P0937A from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human SNX3, His-tagged - SNX3-3584H from Creative Biomart Category Protein

Recombinant Human SNX3, His-tagged - SNX3-31428TH from Creative Biomart Category Protein Source E. coli

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