| Gene Symbol |
SPTBN1
|
| Entrez Gene |
6711
|
| Alt Symbol |
ELF, HEL102, SPTB2, betaSpII
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spectrin, beta, non-erythrocytic 1
|
| Other Description |
beta-G spectrin|beta-II spectrin|beta-fodrin|beta-spectrin 2|beta-spectrin II|beta-spectrin non-erythrocytic 1|embryonic liver beta-fodrin|epididymis luminal protein 102|fodrin beta chain|spectrin beta chain, brain 1|spectrin beta chain, non-erythrocytic 1|spectrin, non-erythroid beta chain 1
|
| Swissprots |
Q59ER3 Q01082 Q8IX99 Q53R99 O60837 B2RP63 Q16057
|
| Accessions |
AAX93104 AAY24229 CAB91088 CBX47472 CBX47473 EAX00137 EAX00138 EAX00139 EAX00140 EAX00141 EAX00142 EAX00143 EAX00144 EAX00145 EAX00146 EAX00147 Q01082 AB209551 BAD92788 AB209748 BAD92985 AB371586 BAG48315 AF218848 AAL56651 AF327441 AAO15362 AJ005694 CAA06678 AK023762 AK025071 AK093946 AK295570 BAG58470 AL117605 BC009640 BC032061 BC137282 AAI37283 BC137283 AAI37284 BM679686 BP218428 BP312037 CR980403 EU794662 ACJ13716 JQ599728 AFX60968 S65762 AAB28324 XM_005264517 XP_005264574 XM_005264518 XP_005264575 XM_006712087 XP_006712150 NM_003128 NP_003119 NM_178313 NP_842565
|
| Function |
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. {ECO:0000250}.
|
| Tissue Specificity |
Isoform 2 is present in brain, lung and kidney (at protein level). {ECO:0000269|PubMed:11665863}.
|
