Gene Symbol | GMPR2 |
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Entrez Gene | 51292 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | guanosine monophosphate reductase 2 |
Other Description | GMP reductase 2|guanosine 5'-monophosphate oxidoreductase 2|guanosine monophosphate reductase isolog |
Swissprots | Q9P2T1 Q86T14 Q6IAJ8 Q567T0 D3DS66 |
Accessions | EAW66051 EAW66052 EAW66053 EAW66054 EAW66055 EAW66056 EAW66057 EAW66058 Q9P2T1 AB032903 BAA93080 AF086919 AAP97149 AF135159 AAG09132 AF419346 AAN32701 AK226166 AV660418 BC003053 AAH03053 BC008021 AAH08021 BC009832 AAH09832 BC093039 AAH93039 BE003291 BI259066 BP347823 BX161436 CAD61908 BX161518 CAD61951 BX247993 CAD62327 BX375671 CA447126 CR457156 CAG33437 HQ447583 ADQ32069 XM_005267740 XP_005267797 XM_005267741 XP_005267798 XM_005267742 XP_005267799 XM_006720165 XP_006720228 NM_001002000 NP_001002000 NM_001002001 NP_001002001 NM_001002002 NP_001002002 NM_001283021 NP_001269950 NM_001283022 NP_001269951 NM_001283023 NP_001269952 NM_016576 NP_057660 NR_104265 |
Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation. {ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231, ECO:0000269|PubMed:16359702, ECO:0000269|PubMed:22037469}. |
Tissue Specificity | Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231}. |
Top Pathways | Purine metabolism |
GMPR2 CRISPR/Cas9 KO Plasmid (h) - sc-409935 from Santa Cruz Biotechnology
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GMPR2 HDR Plasmid (h) - sc-409935-HDR from Santa Cruz Biotechnology
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GMPR2 Double Nickase Plasmid (h) - sc-409935-NIC from Santa Cruz Biotechnology
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GMPR2 Double Nickase Plasmid (h2) - sc-409935-NIC-2 from Santa Cruz Biotechnology
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GMPR2 CRISPR Activation Plasmid (h) - sc-409935-ACT from Santa Cruz Biotechnology
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GMPR2 CRISPR Activation Plasmid (h2) - sc-409935-ACT-2 from Santa Cruz Biotechnology
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GMPR2 Lentiviral Activation Particles (h) - sc-409935-LAC from Santa Cruz Biotechnology
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GMPR2 Lentiviral Activation Particles (h2) - sc-409935-LAC-2 from Santa Cruz Biotechnology
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GMPR2 siRNA (h) - sc-92139 from Santa Cruz Biotechnology
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GMPR2 shRNA Plasmid (h) - sc-92139-SH from Santa Cruz Biotechnology
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GMPR2 shRNA (h) Lentiviral Particles - sc-92139-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU061191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9397 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9397 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13004 from Sigma-Aldrich
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GMPR2 siRNA (Human) - CRH9669 from Cohesion Biosciences
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GMPR2 - MBS8209869 from MyBioSource
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shRNA set against Human GMPR2 (NM_016576.3) - SHH304534 from Creative biogene
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shRNA set against Human GMPR2(NM_016576.3) - SHH090767 from Creative biogene
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shRNA set against Human GMPR2(NM_001002000.1) - SHH090771 from Creative biogene
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shRNA set against Human GMPR2(NM_016576.3) - SHH090825 from Creative biogene
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Human GMPR2 siRNA - orb270171 from Biorbyt
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GMPR2 shRNA Plasmid (Human) - CHH9669 from Cohesion Biosciences
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GMPR2 miRNA 3'UTR clone - MiUTR1H-04094 from Creative biogene
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GMPR2 miRNA 3'UTR clone - MiUTR1H-04095 from Creative biogene
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