Gene Symbol |
MYOZ2
|
Entrez Gene |
51778
|
Alt Symbol |
C4orf5, CMH16, CS-1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
myozenin 2
|
Other Description |
FATZ-related protein 2|calcineurin-binding protein calsarcin-1|muscle-specific protein|myozenin-2
|
Swissprots |
Q9HB92 Q9NPC6 O43415
|
Accessions |
AAG13932 CCQ43545 EAW73662 Q9NPC6 AF007160 AAC19160 AF249873 AAF63623 AJ252149 CAB92965 AK313856 BAG36584 AY013295 AAG38938 BC005195 AAH05195 BC017402 AAH17402 BC020932 AAH20932 BM091578 BP370492 BT007214 AAP35878 XM_006714234 XP_006714297 NM_016599 NP_057683
|
Function |
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
|
Subcellular Location |
Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Colocalizes with ACTN1 and PPP3CA at the Z- line of heart and skeletal muscle. {ECO:0000250}.
|
Tissue Specificity |
Expressed specifically in heart and skeletal muscle. {ECO:0000250|UniProtKB:Q9JJW5, ECO:0000269|PubMed:11114196, ECO:0000269|PubMed:11161785}.
|