| Gene Symbol | PSMC3 |
|---|---|
| Entrez Gene | 5702 |
| Alt Symbol | TBP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | proteasome (prosome, macropain) 26S subunit, ATPase, 3 |
| Other Description | 26S protease regulatory subunit 6A|26S proteasome AAA-ATPase subunit RPT5|TBP-1|Tat-binding protein 1|human immunodeficiency virus tat transactivator binding protein-1|proteasome 26S subunit ATPase 3|proteasome subunit P50 |
| Swissprots | Q3B757 Q53HU5 B2R8V1 Q6IBS1 Q6GPG8 Q3B865 P17980 Q96HD3 |
| Accessions | EAW67916 P17980 AK222485 BAD96205 AK291896 BAF84585 AK313518 BAG36298 BC008713 AAH08713 BC073165 AAH73165 BC106920 AAI06921 BC107804 AAI07805 BP284685 CR456731 CAG33012 DQ892981 ABM83907 DQ896229 ABM87228 M34079 AAA36666 XM_011520232 XP_011518534 XM_011520233 XP_011518535 NM_002804 NP_002795 |
| Function | The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation. {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}. |
| Top Pathways | Proteasome, Epstein-Barr virus infection |