| Gene Symbol |
PSMC3
|
| Entrez Gene |
5702
|
| Alt Symbol |
TBP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) 26S subunit, ATPase, 3
|
| Other Description |
26S protease regulatory subunit 6A|26S proteasome AAA-ATPase subunit RPT5|TBP-1|Tat-binding protein 1|human immunodeficiency virus tat transactivator binding protein-1|proteasome 26S subunit ATPase 3|proteasome subunit P50
|
| Swissprots |
Q3B757 Q53HU5 B2R8V1 Q6IBS1 Q6GPG8 Q3B865 P17980 Q96HD3
|
| Accessions |
EAW67916 P17980 AK222485 BAD96205 AK291896 BAF84585 AK313518 BAG36298 BC008713 AAH08713 BC073165 AAH73165 BC106920 AAI06921 BC107804 AAI07805 BP284685 CR456731 CAG33012 DQ892981 ABM83907 DQ896229 ABM87228 M34079 AAA36666 XM_011520232 XP_011518534 XM_011520233 XP_011518535 NM_002804 NP_002795
|
| Function |
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation. {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.
|
| Top Pathways |
Proteasome, Epstein-Barr virus infection
|
![Western Blot: PSMC3 Overexpression Lysate (Adult Normal) [NBL1-14888] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PSMC3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7625_PSMC3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14888-img0002.jpg)