Gene Symbol | PSMC3 |
---|---|
Entrez Gene | 5702 |
Alt Symbol | TBP1 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) 26S subunit, ATPase, 3 |
Other Description | 26S protease regulatory subunit 6A|26S proteasome AAA-ATPase subunit RPT5|TBP-1|Tat-binding protein 1|human immunodeficiency virus tat transactivator binding protein-1|proteasome 26S subunit ATPase 3|proteasome subunit P50 |
Swissprots | Q3B757 Q53HU5 B2R8V1 Q6IBS1 Q6GPG8 Q3B865 P17980 Q96HD3 |
Accessions | EAW67916 P17980 AK222485 BAD96205 AK291896 BAF84585 AK313518 BAG36298 BC008713 AAH08713 BC073165 AAH73165 BC106920 AAI06921 BC107804 AAI07805 BP284685 CR456731 CAG33012 DQ892981 ABM83907 DQ896229 ABM87228 M34079 AAA36666 XM_011520232 XP_011518534 XM_011520233 XP_011518535 NM_002804 NP_002795 |
Function | The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation. {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}. |
Top Pathways | Proteasome, Epstein-Barr virus infection |
PSMC3 CRISPR/Cas9 KO Plasmid (h) - sc-406458 from Santa Cruz Biotechnology
|
||||||||
PSMC3 HDR Plasmid (h) - sc-406458-HDR from Santa Cruz Biotechnology
|
||||||||
PSMC3 Double Nickase Plasmid (h) - sc-406458-NIC from Santa Cruz Biotechnology
|
||||||||
PSMC3 Double Nickase Plasmid (h2) - sc-406458-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PSMC3 CRISPR Activation Plasmid (h) - sc-406458-ACT from Santa Cruz Biotechnology
|
||||||||
PSMC3 CRISPR Activation Plasmid (h2) - sc-406458-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PSMC3 Lentiviral Activation Particles (h) - sc-406458-LAC from Santa Cruz Biotechnology
|
||||||||
PSMC3 Lentiviral Activation Particles (h2) - sc-406458-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PSMC3 siRNA (h) - sc-76275 from Santa Cruz Biotechnology
|
||||||||
PSMC3 shRNA Plasmid (h) - sc-76275-SH from Santa Cruz Biotechnology
|
||||||||
PSMC3 shRNA (h) Lentiviral Particles - sc-76275-V from Santa Cruz Biotechnology
|
||||||||
PSMC3 RNAi - H00005702-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU107331 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17609 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17609 from Sigma-Aldrich
|
||||||||
PSMC3 siRNA (Human) - CRH3849 from Cohesion Biosciences
|
||||||||
shRNA set against Human PSMC3 (NM_002804.4) - SHH385288 from Creative biogene
|
||||||||
shRNA set against Human PSMC3(NM_002804.4) - SHR147894 from Creative biogene
|
||||||||
Human PSMC3 siRNA - orb264351 from Biorbyt
|
||||||||
PSMC3 shRNA Plasmid (Human) - CHH3849 from Cohesion Biosciences
|
||||||||
PSMC3 miRNA 3'UTR clone - MiUTR1H-08385 from Creative biogene
|