EFNA5
| Gene Symbol | EFNA5 |
|---|---|
| Entrez Gene | 1946 |
| Alt Symbol | AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS |
| Species | Human |
| Gene Type | protein-coding |
| Description | ephrin-A5 |
| Other Description | AL-1|LERK-7|eph-related receptor tyrosine kinase ligand 7 |
| Swissprots | P52803 |
| Accessions | EAW49063 EAW49064 EAW49065 P52803 AK025909 AK308672 BC075054 AAH75054 BC075055 AAH75055 U26403 AAB60377 XM_006714565 XP_006714628 XM_011543250 XP_011541552 XM_011543251 XP_011541553 NM_001962 NP_001953 |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fascicu |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Membrane, caveola {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Note=Compartmentalized in discrete caveolae-like membrane microdomains. |
| Top Pathways | Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway |
Human Ephrin A5 protein fragment - ab114463 from Abcam
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Mouse Ephrin A5 full length protein - ab185830 from Abcam
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EFNA5 / Ephrin A5 Antibody Blocking Peptide - LS-E27252 from LifeSpan Bioscience
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EFNA5 / Ephrin A5 Antibody Blocking Peptide - LS-E23821 from LifeSpan Bioscience
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EFNA5 / Ephrin A5 Antibody Blocking Peptide - LS-E23822 from LifeSpan Bioscience
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Ephrin-A5 Partial Recombinant Protein - H00001946-Q01 from Novus Biologicals
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Recombinant Human Ephrin-A5 Fc Chimera, CF - 374-EA-200 from R&D Systems
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Recombinant Human Ephrin-A5 Fc Chimera Biotinylated Protein - BT374 from R&D Systems
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Recombinant rat Ephrin-A5 (OPCA00075) - OPCA00075 from Aviva Systems Biology
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Recombinant rat Ephrin-A5 (OPCA01232) - OPCA01232 from Aviva Systems Biology
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Ephrin-A5 - H00001946-Q01-10 from Acris Antibodies
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Ephrin-A5 - H00001946-Q01-25 from Acris Antibodies
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EFNA5 fusion protein - ag12408 from Proteintech Group
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EFNA5 fusion protein - Ag12179 from Proteintech Group
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Recombinant Human EFNA5, Fc tagged - EFNA5-79H from Creative Biomart
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Recombinant Human EFNA5, His tagged - EFNA5-700H from Creative Biomart
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Recombinant Human EFNA5 - EFNA5-28471TH from Creative Biomart
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Recombinant Human Ephrin-A5 - EFNA5-1611H from Creative Biomart
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Ephrin-A5 - PN201556 from Elabscience
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Recombinant Ephrin A5 (EFNA5) - RPE111Hu01 from Uscn Life Science Inc.
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Human Ephrin-A5 / EFNA5 Protein (Fc Tag) - 10192-H02H-100 from Sino Biological
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Human Ephrin-A5 / EFNA5 Protein (His Tag) - 10192-H08H-100 from Sino Biological
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Ephrin A5 Blocking Peptide - CBP3909 from Cohesion Biosciences
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Ephrin-A5 (P63) Peptide - BS2478P from Bioworld Technology
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Recombinant Ephrin A5 (EFNA5) - RPE111Hu01 from Cloud-clone
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