Gene Symbol | CNDP2 |
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Entrez Gene | 55748 |
Alt Symbol | CN2, CPGL, HEL-S-13, HsT2298, PEPA |
Species | Human |
Gene Type | protein-coding |
Description | CNDP dipeptidase 2 (metallopeptidase M20 family) |
Other Description | cytosolic non-specific dipeptidase|cytosolic nonspecific dipeptidase|epididymis secretory protein Li 13|glutamate carboxypeptidase-like protein 1|peptidase A |
Swissprots | Q9NVB4 Q9BQ94 B3KUG4 Q8WY59 Q96KP4 |
Accessions | CAD56843 CCQ43593 EAW66550 EAW66551 EAW66552 EAW66553 EAW66554 EAW66555 EAW66556 EAW66557 EAW66558 Q96KP4 AF258592 AAG23795 AJ347717 CAC69883 AK001262 BAA91587 AK001692 BAA91840 AK001983 BAA92018 AK024471 BAB15761 AK092863 AK097155 BAG53426 AK298309 BAG60563 AK300904 BAG62540 BC001375 AAH01375 BC003176 AAH03176 BM675304 BQ183399 DC313148 DC392026 EU794600 ACJ13654 XM_005266728 XP_005266785 XM_006722503 XP_006722566 XM_011526071 XP_011524373 XM_011526072 XP_011524374 XM_011526073 XP_011524375 NM_001168499 NP_001161971 NM_018235 NP_060705 |
Function | Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. {ECO:0000269|PubMed:17121880, ECO:0000269|PubMed:19346245}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880}. |
Tissue Specificity | Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880}. |
Top Pathways | Arginine and proline metabolism, Histidine metabolism, beta-Alanine metabolism |
CNDP2 CRISPR/Cas9 KO Plasmid (h) - sc-410028 from Santa Cruz Biotechnology
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CNDP2 HDR Plasmid (h) - sc-410028-HDR from Santa Cruz Biotechnology
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CNDP2 Double Nickase Plasmid (h) - sc-410028-NIC from Santa Cruz Biotechnology
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CNDP2 Double Nickase Plasmid (h2) - sc-410028-NIC-2 from Santa Cruz Biotechnology
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CNDP2 CRISPR Activation Plasmid (h) - sc-410028-ACT from Santa Cruz Biotechnology
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CNDP2 CRISPR Activation Plasmid (h2) - sc-410028-ACT-2 from Santa Cruz Biotechnology
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CNDP2 Lentiviral Activation Particles (h) - sc-410028-LAC from Santa Cruz Biotechnology
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CNDP2 Lentiviral Activation Particles (h2) - sc-410028-LAC-2 from Santa Cruz Biotechnology
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CNDP2 siRNA (h) - sc-72935 from Santa Cruz Biotechnology
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CNDP2 shRNA Plasmid (h) - sc-72935-SH from Santa Cruz Biotechnology
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CNDP2 shRNA (h) Lentiviral Particles - sc-72935-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU091981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6300 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6300 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07552 from Sigma-Aldrich
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CNDP2 siRNA (Human) - CRJ0886 from Cohesion Biosciences
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Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL RNAi - H00055748-R01 from Novus Biologicals
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CNDP2 - MBS8201695 from MyBioSource
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shRNA set against Human CNDP2 (NM_018235.2) - SHH266129 from Creative biogene
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Human CNDP2 siRNA - orb271387 from Biorbyt
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CNDP2 shRNA Plasmid (Human) - CHJ0886 from Cohesion Biosciences
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CNDP2 miRNA 3'UTR clone - MiUTR4H-TG02210 from Creative biogene
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