Gene Symbol | TNXB |
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Entrez Gene | 7148 |
Alt Symbol | EDS3, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS |
Species | Human |
Gene Type | protein-coding |
Description | tenascin XB |
Other Description | growth-inhibiting protein 45|hexabrachion-like protein|tenascin XB1|tenascin XB2|tenascin-X |
Swissprots | Q5ST74 Q9UC11 Q5SQD3 Q9UC12 Q59GU7 Q08AM0 Q9UC13 P78530 Q9UC10 Q9UMG7 Q8N4R1 P22105 Q7L8Q4 Q9NPK9 Q08424 Q08AM1 P78531 |
Accessions | AAB47488 AAB67981 CAA50740 CAA74110 CAB89296 CAB89297 CAB89298 CAB89299 CAB89300 EAX03572 EAX03573 EAX03574 EAX03575 EAX03576 EAX03577 EAX03578 EAX03579 P22105 AB209012 BAD92249 AK310080 AL044866 BC033740 AAH33740 BC071883 AAH71883 BC125114 AAI25115 BC125115 AAI25116 BC130037 AAI30038 BI010479 BP233293 BP420628 BQ446909 EU219621 ACA14133 JF432266 ADZ15483 M25813 AAA35884 U24488 AAB41287 U52699 AAC50880 U52700 AAC50882 X71923 CAA50739 X71927 Y13782 CAA74109 Y17865 CAA76899 Y17866 CAA76900 Y17867 CAA76901 Y17868 CAA76902 NM_019105 NP_061978 NM_032470 NP_115859 |
Function | Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. {ECO:0000269|PubMed:17033827}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Tissue Specificity | Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB- short is only expressed in the adrenal gland. |
Top Pathways | Focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway, MicroRNAs in cancer |
Tenascin-X CRISPR/Cas9 KO Plasmid (h) - sc-402418 from Santa Cruz Biotechnology
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Tenascin-X HDR Plasmid (h) - sc-402418-HDR from Santa Cruz Biotechnology
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Tenascin-X Double Nickase Plasmid (h) - sc-402418-NIC from Santa Cruz Biotechnology
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Tenascin-X Double Nickase Plasmid (h2) - sc-402418-NIC-2 from Santa Cruz Biotechnology
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Tenascin-X CRISPR Activation Plasmid (h) - sc-402418-ACT from Santa Cruz Biotechnology
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Tenascin-X CRISPR Activation Plasmid (h2) - sc-402418-ACT-2 from Santa Cruz Biotechnology
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Tenascin-X Lentiviral Activation Particles (h) - sc-402418-LAC from Santa Cruz Biotechnology
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Tenascin-X Lentiviral Activation Particles (h2) - sc-402418-LAC-2 from Santa Cruz Biotechnology
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Tenascin-X siRNA (h) - sc-43188 from Santa Cruz Biotechnology
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Tenascin-X shRNA Plasmid (h) - sc-43188-SH from Santa Cruz Biotechnology
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Tenascin-X shRNA (h) Lentiviral Particles - sc-43188-V from Santa Cruz Biotechnology
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Tenascin X RNAi - H00007148-R01 from Novus Biologicals
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Tenascin X RNAi - H00007148-R02 from Novus Biologicals
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MISSION® esiRNA - EHU159451 from Sigma-Aldrich
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MISSION® esiRNA - EHU106261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2443 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2443 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00591 from Sigma-Aldrich
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TNXB siRNA (Human) - CRH4904 from Cohesion Biosciences
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TNXB - MBS8237346 from MyBioSource
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shRNA set against Human TNXB (NM_019105.6) - SHH432604 from Creative biogene
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TNXB shRNA Plasmid (Human) - CHH4904 from Cohesion Biosciences
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TNXB miRNA 3'UTR clone - MiUTR3H-03789 from Creative biogene
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TNXB miRNA 3'UTR clone - MiUTR3H-03790 from Creative biogene
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