| Gene Symbol | BAAT |
|---|---|
| Entrez Gene | 570 |
| Alt Symbol | BACAT, BAT |
| Species | Human |
| Gene Type | protein-coding |
| Description | bile acid CoA:amino acid N-acyltransferase |
| Other Description | bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)|bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)|bile acid-CoA:amino acid N-acyltransferase|long-chain fatty-acyl-CoA hydrolase |
| Swissprots | Q14032 Q96L31 Q3B7W9 |
| Accessions | EAW58943 EAW58944 EAW58945 EAW58946 Q14032 AK315347 BC009567 AAH09567 BC039200 BC107424 AAI07425 BG565737 CB154234 CR541918 CAG46716 DQ891910 ABM82836 DQ895095 ABM86021 H62757 L34081 AAC37550 NM_001127610 NP_001121082 NM_001701 NP_001692 |
| Function | Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very lo |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12810727}. |
| Tissue Specificity | Expressed in liver, gallbladder mucosa and pancreas. {ECO:0000269|PubMed:12810727, ECO:0000269|PubMed:2037576}. |
| Top Pathways | Primary bile acid biosynthesis, Peroxisome, Bile secretion, Taurine and hypotaurine metabolism, Biosynthesis of unsaturated fatty acids |