Gene Symbol | KCNE4 |
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Entrez Gene | 23704 |
Alt Symbol | MIRP3 |
Species | Human |
Gene Type | protein-coding |
Description | potassium channel, voltage gated subfamily E regulatory beta subunit 4 |
Other Description | MINK-related peptide 3|cardiac voltage-gated potassium channel accessory subunit 4|minimum potassium ion channel-related peptide 3|potassium channel subunit beta MiRP3|potassium voltage-gated channel subfamily E member 4|potassium voltage-gated channel, Isk-related family, member 4 |
Swissprots | Q8WWG9 Q96CC4 B7Z275 Q53SM4 |
Accessions | AAX93228 ABQ01241 EAW70810 Q8WWG9 AK294423 BAH11761 AK313203 BAG36019 AY065987 AAL49979 BC014429 AAH14429 BM662449 BP348485 BP359441 BP362695 DQ192293 ABB00306 DQ892516 ABM83442 EU176698 ABW03499 NM_080671 NP_542402 |
Function | Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart. {ECO:0000269|PubMed:12096056}. |
KCNE4 CRISPR/Cas9 KO Plasmid (h) - sc-408093 from Santa Cruz Biotechnology
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KCNE4 HDR Plasmid (h) - sc-408093-HDR from Santa Cruz Biotechnology
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KCNE4 Double Nickase Plasmid (h) - sc-408093-NIC from Santa Cruz Biotechnology
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KCNE4 Double Nickase Plasmid (h2) - sc-408093-NIC-2 from Santa Cruz Biotechnology
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KCNE4 CRISPR Activation Plasmid (h) - sc-408093-ACT from Santa Cruz Biotechnology
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KCNE4 CRISPR Activation Plasmid (h2) - sc-408093-ACT-2 from Santa Cruz Biotechnology
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KCNE4 Lentiviral Activation Particles (h) - sc-408093-LAC from Santa Cruz Biotechnology
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KCNE4 Lentiviral Activation Particles (h2) - sc-408093-LAC-2 from Santa Cruz Biotechnology
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KCNE4 siRNA (h) - sc-45535 from Santa Cruz Biotechnology
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KCNE4 shRNA Plasmid (h) - sc-45535-SH from Santa Cruz Biotechnology
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KCNE4 shRNA (h) Lentiviral Particles - sc-45535-V from Santa Cruz Biotechnology
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MiRP3 RNAi - H00023704-R01 from Novus Biologicals
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MISSION® esiRNA - EHU016381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10936 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10936 from Sigma-Aldrich
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shRNA set against Human KCNE4 (NM_080671.2) - SHH322963 from Creative biogene
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shRNA set against Human KCNE4(NM_080671.2) - SHL188956 from Creative biogene
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KCNE4 miRNA 3'UTR clone - MiUTR1H-05107 from Creative biogene
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