Gene Symbol | CD1E |
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Entrez Gene | 913 |
Alt Symbol | CD1A, R2 |
Species | Human |
Gene Type | protein-coding |
Description | CD1e molecule |
Other Description | CD1E antigen, e polypeptide|R2G1|T-cell surface glycoprotein CD1e, membrane-associated|differentiation antigen CD1-alpha-3|hCD1e|leukocyte differentiation antigen|thymocyte antigen CD1E |
Swissprots | Q5TDK4 Q712F0 Q712E9 Q712E6 E7EP01 P15812 Q96TD0 Q712E7 B4DZV3 Q5TDK6 Q5TDK8 Q96TD1 Q712E4 Q712F5 Q9UMM1 Q5TDJ9 Q712F3 Q712F2 Q5TDK5 Q5TDL1 Q9Y5M3 Q712E5 Q5TDK3 Q712F4 Q712E8 Q712F1 |
Accessions | AAA51937 AAD37582 CAA33100 CAB82829 CAC07175 EAW52828 EAW52829 EAW52830 EAW52831 EAW52832 EAW52833 EAW52834 EAW52835 EAW52836 EAW52837 EAW52838 EAW52839 EAW52840 P15812 AA283335 AA354546 AJ289111 CAB93150 AJ289112 CAB93151 AJ289113 CAB93152 AJ289114 CAB93153 AJ289115 CAB93154 AJ289116 CAB93155 AJ289117 CAB93156 AJ289118 CAB93157 AJ289119 CAB93158 AJ289120 CAB93159 AJ289121 CAB93160 AJ289122 CAB93161 AK303088 BAG64199 AK303108 BAG64215 AK303217 BAG64304 AK303233 BAG64319 AK303542 BAG64568 AK310567 AK311643 BC131693 AAI31694 DA827206 DC406237 X79517 CAA56053 X79518 CAA56054 X79519 CAA56055 XM_011510133 XP_011508435 XM_011510134 XP_011508436 XM_011510135 XP_011508437 NM_001042583 NP_001036048 NM_001042584 NP_001036049 NM_001042585 NP_001036050 NM_001042586 NP_001036051 NM_001042587 NP_001036052 NM_001185107 NP_001172036 NM_001185108 NP_001172037 NM_001185110 NP_001172039 NM_001185112 NP_001172041 NM_001185113 NP_001172042 NM_001185114 NP_001172043 NM_001185115 NP_001172044 NM_030893 NP_112155 |
Function | T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane- associated form is not active. {ECO:0000269|PubMed:10948205, ECO:0000269|PubMed:16311334, ECO:0000269|PubMed:21788486}. |
Subcellular Location | T-cell surface glycoprotein CD1e, membrane- associated: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells. |
Tissue Specificity | Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues. {ECO:0000269|PubMed:10948205}. |
Top Pathways | Hematopoietic cell lineage |
Human CD1E protein fragment - ab177643 from Abcam
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CD1A Antibody Blocking Peptide - LS-E2502 from LifeSpan Bioscience
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CD1A Antibody Blocking Peptide - LS-E23000 from LifeSpan Bioscience
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CD1E Antibody Blocking Peptide - LS-E23128 from LifeSpan Bioscience
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CD1E Antibody Blocking Peptide - LS-E10406 from LifeSpan Bioscience
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Recombinant Human CD1a Protein - H00000909-P01 from Novus Biologicals
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CD1E-Antibody-Center-Blocking-peptide - BP9942c from Abgent, a WuXi AppTec company
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Human CD1a (HEK293 Lysate) - orb197720 from Biorbyt
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CD1E protein (His tag) - 80R-3742 from Fitzgerald
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RRM2 protein (His tag) - 80R-1345 from Fitzgerald
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CD1e Blocking Peptide - abx062370 from Abbexa
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CD1e (His-tag) - AR51429PU-N from Acris Antibodies
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CD1e (His-tag) - AR51429PU-S from Acris Antibodies
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Recombinant Human CD1a (HEK293 Lysate) - 230-10011 from RayBiotech
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CD1E, 32- 305aa Human, His tag, E.coli - 01-P2609 from ARP American Research Products
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CD1A fusion protein - ag0424 from Proteintech Group
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CD1E fusion protein - ag18008 from Proteintech Group
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CD1E fusion protein - Ag19054 from Proteintech Group
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CD1E, 32- 305aa Human, His tag, E.coli - GWB-ATG0D3 from Genway Biotech
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Recombinant Human CD1E, His-tagged - CD1E-5113H from Creative Biomart
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Recombinant Human CD1e molecule, His-tagged - CD1E-512H from Creative Biomart
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RRM2 1-389aa - CMB-415 from Reagent Proteins
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Recombinant Cluster Of Differentiation 1e (CD1e) - RPB170Hu01 from Uscn Life Science Inc.
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CD1e Blocking Peptide - CBP1176 from Cohesion Biosciences
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CD1E Peptide - BS5652P from Bioworld Technology
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