ANGPT1

Gene Symbol ANGPT1
Entrez Gene 284
Alt Symbol AGP1, AGPT, ANG1
Species Human
Gene Type protein-coding
Description angiopoietin 1
Other Description ANG-1|angiopoietin-1
Swissprots Q15389 Q5HYA0
Accessions EAW91909 EAW91910 EAW91911 EAW91912 Q15389 AB084454 BAB91325 AK300319 BAG62071 AK304717 BAG65481 AL700429 AW069541 AY055342 AAL59669 AY121504 AAM81745 AY124380 AAM92271 BC029406 AAH29406 BC152411 AAI52412 BC152419 AAI52420 BC166662 AAI66662 BX648814 CAI45984 CX867178 D13628 BAA02793 EU831933 ACE87374 EU832028 ACE86690 U83508 AAB50557 XR_928319 NM_001146 NP_001137 NM_001199859 NP_001186788 NM_139290
Function Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adh
Subcellular Location Secreted.
Top Pathways Rheumatoid arthritis, PI3K-Akt signaling pathway, Rap1 signaling pathway

Ang-1 (C-19) - sc-6320 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ang-1 (C-19): sc-6320. Western blot analysis of Ang-1 expression in HeLa whole cell lysate.

Ang-1 (N-18) - sc-6319 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ang-1 (N-18): sc-6319. Immunofluorescence staining of methanol-fixed ECV304 cells showing cytoplasmic localization.

Ang (H-98) - sc-8357 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ang (H-98): sc-8357. Western blot analysis of angiopoietin expression in ECV304 whole cell lysate.

Anti-Angiopoietin 1 antibody - ab8451 from Abcam

Prices $394.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Supernatants of mouse-angiopoietin-expressing endothelial cells.Lane 1 - wt endothelial cell Lane 2 - mouse Ang-1 (clone 1-8) expressing cells Lane 3 - mouse Ang-1 (clone 1-15) expressing cells Lane 4 - mouse Ang-2 (clone 2-9) expressing cells Marion Scharpfenecker 2002

Anti-Angiopoietin 1 antibody - ab94684 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab94684, at 1/100 dilution, staining Angiopoietin 1 in formalin fixed, paraffin embedded human heart tissue by Immunohistochemistry.

Anti-Angiopoietin 1 antibody - ab134504 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab134504 stained MCF7 cells. The cells were 4% formaldehdye fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab134504, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Angiopoietin 1 antibody [171718] - ab49694 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 171718

Anti-Angiopoietin 1 antibody [EPR2888(N)] - ab183701 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2888(N)
All lanes : Anti-Angiopoietin 1 antibody [EPR2888(N)] (ab183701) at 1/50000 dilutionLane 1 : U87-MG cell lysateLane 2 : HeLa cell lysateLane 3 : K562 cell lysateLane 4 : ECV-304 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Angiopoietin 1 antibody [EPR2889(N)] - ab183702 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2889(N)
All lanes : Anti-Angiopoietin 1 antibody [EPR2889(N)] (ab183702) at 1/5000 dilutionLane 1 : U87-MG cell lysateLane 2 : ECV-304 cell lysateLane 3 : K562 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-ANGPT1 / Angiopoietin-1 Antibody (N-Terminus) IHC-plus™ - LS-B62 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ANGPT1 / Angiopoietin-1 antibody IHC staining of mouse kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B62 dilution 1:200.

Anti-ANGPT1 / Angiopoietin-1 Antibody - LS-C3693 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody - LS-C69009 from LifeSpan Bioscience

Prices $575.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody - LS-C86954 from LifeSpan Bioscience

Prices $710.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody (N-Terminus) - LS-C84135 from LifeSpan Bioscience

Prices $605.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody - LS-C3692 from LifeSpan Bioscience

Prices $590.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody - LS-C125075 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody (clone 171606) - LS-C149882 from LifeSpan Bioscience

Prices $385.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 171606

Anti-ANGPT1 / Angiopoietin-1 Antibody (aa278-295, Magnetic beads) - LS-C172154 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody (aa278-295, Sepharose) - LS-C172155 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody (clone 15D3) - LS-C194759 from LifeSpan Bioscience

Prices $740.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 15D3

Anti-ANGPT1 / Angiopoietin-1 Antibody (N-Terminus) - LS-C146240 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ANGPT1 / Angiopoietin-1 antibody LS-C146240 Western blot of ACHN Cell lysate. Antibody concentration 1 ug/ml.

Anti-ANGPT1 / Angiopoietin-1 Antibody (aa378-410, AP) - LS-C251292 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody (aa378-410, APC) - LS-C251293 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody (aa378-410, FITC) - LS-C251294 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANGPT1 / Angiopoietin-1 Antibody (aa378-410, PE) - LS-C251298 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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