| Gene Symbol | ANGPT1 |
|---|---|
| Entrez Gene | 284 |
| Alt Symbol | AGP1, AGPT, ANG1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | angiopoietin 1 |
| Other Description | ANG-1|angiopoietin-1 |
| Swissprots | Q15389 Q5HYA0 |
| Accessions | EAW91909 EAW91910 EAW91911 EAW91912 Q15389 AB084454 BAB91325 AK300319 BAG62071 AK304717 BAG65481 AL700429 AW069541 AY055342 AAL59669 AY121504 AAM81745 AY124380 AAM92271 BC029406 AAH29406 BC152411 AAI52412 BC152419 AAI52420 BC166662 AAI66662 BX648814 CAI45984 CX867178 D13628 BAA02793 EU831933 ACE87374 EU832028 ACE86690 U83508 AAB50557 XR_928319 NM_001146 NP_001137 NM_001199859 NP_001186788 NM_139290 |
| Function | Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adh |
| Subcellular Location | Secreted. |
| Top Pathways | Rheumatoid arthritis, PI3K-Akt signaling pathway, Rap1 signaling pathway |
Ang-1 CRISPR/Cas9 KO Plasmid (h) - sc-416736 from Santa Cruz Biotechnology
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Ang-1 HDR Plasmid (h) - sc-416736-HDR from Santa Cruz Biotechnology
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Ang-1 Double Nickase Plasmid (h) - sc-416736-NIC from Santa Cruz Biotechnology
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Ang-1 Double Nickase Plasmid (h2) - sc-416736-NIC-2 from Santa Cruz Biotechnology
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Ang-1 CRISPR Activation Plasmid (h) - sc-416736-ACT from Santa Cruz Biotechnology
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Ang-1 CRISPR Activation Plasmid (h2) - sc-416736-ACT-2 from Santa Cruz Biotechnology
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Ang-1 Lentiviral Activation Particles (h) - sc-416736-LAC from Santa Cruz Biotechnology
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Ang-1 Lentiviral Activation Particles (h2) - sc-416736-LAC-2 from Santa Cruz Biotechnology
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Ang siRNA (h) - sc-37198 from Santa Cruz Biotechnology
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Ang shRNA Plasmid (h) - sc-37198-SH from Santa Cruz Biotechnology
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Ang shRNA (h) Lentiviral Particles - sc-37198-V from Santa Cruz Biotechnology
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Ang-1 siRNA (h) - sc-39303 from Santa Cruz Biotechnology
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Ang-1 shRNA Plasmid (h) - sc-39303-SH from Santa Cruz Biotechnology
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Ang-1 shRNA (h) Lentiviral Particles - sc-39303-V from Santa Cruz Biotechnology
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Ang-1/4 siRNA (h) - sc-43614 from Santa Cruz Biotechnology
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Ang-1/4 shRNA Plasmid (h) - sc-43614-SH from Santa Cruz Biotechnology
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Ang-1/4 shRNA (h) Lentiviral Particles - sc-43614-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU033671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1934 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1934 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11538 from Sigma-Aldrich
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ANGPT1 siRNA (Human) - CRH0197 from Cohesion Biosciences
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ANGPT1 - MBS8223050 from MyBioSource
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shRNA set against Human ANGPT1 (NM_001146.3) - SHH236226 from Creative biogene
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shRNA set against Human ANGPT1(NM_001146.3) - SHG057645 from Creative biogene
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