Gene Symbol | TFB1M |
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Entrez Gene | 51106 |
Alt Symbol | CGI-75, CGI75, mtTFB, mtTFB1 |
Species | Human |
Gene Type | protein-coding |
Description | transcription factor B1, mitochondrial |
Other Description | S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1|dimethyladenosine transferase 1, mitochondrial|h-mtTFB1|hTFB1M|homolog of yeast mitochondrial transcription factor B|mitochondrial 12S rRNA dimethylase 1|mitochondrial dimethyladenosine transferase 1 |
Swissprots | Q9Y384 Q05DR0 Q8WVM0 |
Accessions | ADP92254 ADP92255 ADP92256 ADP92257 ADP92258 ADP92259 ADP92260 ADP92261 ADP92262 ADP92263 ADP92264 ADP92265 ADP92266 ADP92267 ADP92268 ADP92269 ADP92270 ADP92271 ADP92272 ADP92273 ADP92274 ADP92275 ADP92276 ADP92277 ADP92278 ADP92279 ADP92280 ADP92281 ADP92282 ADP92283 ADP92284 ADP92285 ADP92286 ADP92287 ADP92288 ADP92289 ADP92290 ADP92291 ADP92292 ADP92293 EAW47690 Q8WVM0 AA405744 AF151833 AAD34070 AK022993 AK289484 BAF82173 BC005183 AAH05183 BC017788 AAH17788 BC054007 BU849912 CA430614 DQ891970 ABM82896 DQ895159 ABM86085 HG499813 XM_005267006 XP_005267063 XM_011535869 XP_011534171 XM_011535870 XP_011534172 XM_011535871 XP_011534173 XM_011535872 XP_011534174 XM_011535873 XP_011534175 XR_942460 NM_016020 NP_057104 |
Function | S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. {ECO:0000269|PubMed:11809803, ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:11809803}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:12068295}. |
TFB1M CRISPR/Cas9 KO Plasmid (h) - sc-406075 from Santa Cruz Biotechnology
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TFB1M HDR Plasmid (h) - sc-406075-HDR from Santa Cruz Biotechnology
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TFB1M Double Nickase Plasmid (h) - sc-406075-NIC from Santa Cruz Biotechnology
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TFB1M Double Nickase Plasmid (h2) - sc-406075-NIC-2 from Santa Cruz Biotechnology
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TFB1M CRISPR Activation Plasmid (h) - sc-406075-ACT from Santa Cruz Biotechnology
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TFB1M CRISPR Activation Plasmid (h2) - sc-406075-ACT-2 from Santa Cruz Biotechnology
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TFB1M Lentiviral Activation Particles (h) - sc-406075-LAC from Santa Cruz Biotechnology
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TFB1M Lentiviral Activation Particles (h2) - sc-406075-LAC-2 from Santa Cruz Biotechnology
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TFB1M siRNA (h) - sc-95185 from Santa Cruz Biotechnology
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TFB1M shRNA Plasmid (h) - sc-95185-SH from Santa Cruz Biotechnology
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TFB1M shRNA (h) Lentiviral Particles - sc-95185-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU031281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21250 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21250 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01818 from Sigma-Aldrich
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TFB1M siRNA (Human) - CRH9527 from Cohesion Biosciences
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TFB1M - MBS8225132 from MyBioSource
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shRNA set against Human TFB1M (NM_016020.3) - SHH426128 from Creative biogene
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TFB1M shRNA Plasmid (Human) - CHH9527 from Cohesion Biosciences
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TFB1M miRNA 3'UTR clone - MiUTR3H-08912 from Creative biogene
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