| Gene Symbol |
SSU72
|
| Entrez Gene |
29101
|
| Alt Symbol |
HSPC182, PNAS-120
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
|
| Other Description |
CTD phosphatase SSU72|RNA polymerase II subunit A C-terminal domain phosphatase SSU72
|
| Swissprots |
Q9H933 Q9NP77 Q9BZS6
|
| Accessions |
EAW56182 EAW56183 Q9NP77 AF161530 AAF29145 AF277178 AAK07538 AF305818 AAK55521 AJ276409 CAC81713 AK001809 BAA91921 AK023110 BAB14410 AK127149 AK129493 AK291324 BAF84013 AK297505 BAG59918 AK310067 BC008070 AAH08070 BC018909 CF594026 DQ892987 ABM83913 DQ896236 ABM87235 NM_014188 NP_054907
|
| Function |
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. {ECO:0000269|PubMed:15659578, ECO:0000269|PubMed:20861839, ECO:0000269|PubMed:23070812}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Predominantly in the cytosol.
|
| Top Pathways |
mRNA surveillance pathway
|
![Western Blot: Ssu72 Overexpression Lysate (Adult Normal) [NBL1-16482] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Ssu72.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1213_Ssu72%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16482-img0002.jpg)