Gene Symbol | SSU72 |
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Entrez Gene | 29101 |
Alt Symbol | HSPC182, PNAS-120 |
Species | Human |
Gene Type | protein-coding |
Description | SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) |
Other Description | CTD phosphatase SSU72|RNA polymerase II subunit A C-terminal domain phosphatase SSU72 |
Swissprots | Q9H933 Q9NP77 Q9BZS6 |
Accessions | EAW56182 EAW56183 Q9NP77 AF161530 AAF29145 AF277178 AAK07538 AF305818 AAK55521 AJ276409 CAC81713 AK001809 BAA91921 AK023110 BAB14410 AK127149 AK129493 AK291324 BAF84013 AK297505 BAG59918 AK310067 BC008070 AAH08070 BC018909 CF594026 DQ892987 ABM83913 DQ896236 ABM87235 NM_014188 NP_054907 |
Function | Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. {ECO:0000269|PubMed:15659578, ECO:0000269|PubMed:20861839, ECO:0000269|PubMed:23070812}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly in the cytosol. |
Top Pathways | mRNA surveillance pathway |
SSU72 CRISPR/Cas9 KO Plasmid (h) - sc-405896 from Santa Cruz Biotechnology
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SSU72 HDR Plasmid (h) - sc-405896-HDR from Santa Cruz Biotechnology
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SSU72 Double Nickase Plasmid (h) - sc-405896-NIC from Santa Cruz Biotechnology
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SSU72 Double Nickase Plasmid (h2) - sc-405896-NIC-2 from Santa Cruz Biotechnology
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SSU72 CRISPR Activation Plasmid (h) - sc-405896-ACT from Santa Cruz Biotechnology
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SSU72 CRISPR Activation Plasmid (h2) - sc-405896-ACT-2 from Santa Cruz Biotechnology
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SSU72 Lentiviral Activation Particles (h) - sc-405896-LAC from Santa Cruz Biotechnology
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SSU72 Lentiviral Activation Particles (h2) - sc-405896-LAC-2 from Santa Cruz Biotechnology
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SSU72 siRNA (h) - sc-76578 from Santa Cruz Biotechnology
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SSU72 shRNA Plasmid (h) - sc-76578-SH from Santa Cruz Biotechnology
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SSU72 shRNA (h) Lentiviral Particles - sc-76578-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU125471 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0871 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0873 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0872 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20638 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20638 from Sigma-Aldrich
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SSU72 siRNA (Human) - CRH9192 from Cohesion Biosciences
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SSU72 - MBS8232218 from MyBioSource
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shRNA set against Human SSU72 (NM_014188.2) - SHH418636 from Creative biogene
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shRNA set against Human SSU72(NM_014188.2) - SHL037080 from Creative biogene
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Human SSU72 siRNA - orb269694 from Biorbyt
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SSU72 shRNA Plasmid (Human) - CHH9192 from Cohesion Biosciences
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SSU72 miRNA 3'UTR clone - MiUTR1H-09934 from Creative biogene
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