| Gene Symbol |
ITGB7
|
| Entrez Gene |
3695
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, beta 7
|
| Other Description |
gut homing receptor beta subunit|integrin beta 7 subunit|integrin beta-7
|
| Swissprots |
Q9UCS7 Q9UCP7 P26010
|
| Accessions |
AAA36118 AAB23688 AGZ05124 AGZ05125 AGZ05126 AGZ05127 AGZ05128 AGZ05129 AGZ05130 AGZ05131 AGZ05132 AGZ05133 AGZ05134 AGZ05135 AGZ05136 AGZ05137 AGZ05138 AGZ05139 AGZ05140 AGZ05141 AGZ05142 AGZ05143 AGZ05144 AGZ05145 AGZ05146 AGZ05147 AGZ05148 AGZ05149 AGZ05150 AGZ05151 AGZ05152 AGZ05153 AGZ05154 AGZ05155 AGZ05156 AGZ05157 AGZ05158 AGZ05159 AGZ05160 AGZ05161 AGZ05162 AGZ05163 AGZ05164 AGZ05165 AGZ05166 AGZ05167 AGZ05168 AGZ05169 AGZ05170 AGZ05171 AGZ05172 AGZ05173 AGZ05174 AGZ05175 AGZ05176 AGZ05177 AGZ05178 AGZ05179 AGZ05180 AGZ05181 AGZ05182 AGZ05183 AGZ05184 AGZ05185 AGZ05186 AGZ05187 AGZ05188 AGZ05189 AGZ05190 AGZ05191 AGZ05192 AGZ05193 AGZ05194 EAW96675 P26010 AI804573 AK298239 BAH12742 AK300960 BAH13382 AK301523 BAH13505 AK311703 BC015916 AAH15916 DC296007 DQ895448 ABM86374 EU176336 ABW03787 M62880 AAA59185 M68892 AAA59184 S80335 AAB21332 XM_005268851 XP_005268908 XM_005268852 XP_005268909 XM_006719376 XP_006719439 XR_429099 NM_000889 NP_000880 NR_104181
|
| Function |
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in a variety of leukocyte lines.
|
| Top Pathways |
Arrhythmogenic right ventricular cardiomyopathy (ARVC), PI3K-Akt signaling pathway, Intestinal immune network for IgA production, Dilated cardiomyopathy, Focal adhesion
|