ITGB7

Gene Symbol ITGB7
Entrez Gene 3695
Alt Symbol -
Species Human
Gene Type protein-coding
Description integrin, beta 7
Other Description gut homing receptor beta subunit|integrin beta 7 subunit|integrin beta-7
Swissprots Q9UCS7 Q9UCP7 P26010
Accessions AAA36118 AAB23688 AGZ05124 AGZ05125 AGZ05126 AGZ05127 AGZ05128 AGZ05129 AGZ05130 AGZ05131 AGZ05132 AGZ05133 AGZ05134 AGZ05135 AGZ05136 AGZ05137 AGZ05138 AGZ05139 AGZ05140 AGZ05141 AGZ05142 AGZ05143 AGZ05144 AGZ05145 AGZ05146 AGZ05147 AGZ05148 AGZ05149 AGZ05150 AGZ05151 AGZ05152 AGZ05153 AGZ05154 AGZ05155 AGZ05156 AGZ05157 AGZ05158 AGZ05159 AGZ05160 AGZ05161 AGZ05162 AGZ05163 AGZ05164 AGZ05165 AGZ05166 AGZ05167 AGZ05168 AGZ05169 AGZ05170 AGZ05171 AGZ05172 AGZ05173 AGZ05174 AGZ05175 AGZ05176 AGZ05177 AGZ05178 AGZ05179 AGZ05180 AGZ05181 AGZ05182 AGZ05183 AGZ05184 AGZ05185 AGZ05186 AGZ05187 AGZ05188 AGZ05189 AGZ05190 AGZ05191 AGZ05192 AGZ05193 AGZ05194 EAW96675 P26010 AI804573 AK298239 BAH12742 AK300960 BAH13382 AK301523 BAH13505 AK311703 BC015916 AAH15916 DC296007 DQ895448 ABM86374 EU176336 ABW03787 M62880 AAA59185 M68892 AAA59184 S80335 AAB21332 XM_005268851 XP_005268908 XM_005268852 XP_005268909 XM_006719376 XP_006719439 XR_429099 NM_000889 NP_000880 NR_104181
Function Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in a variety of leukocyte lines.
Top Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), PI3K-Akt signaling pathway, Intestinal immune network for IgA production, Dilated cardiomyopathy, Focal adhesion

Integrin β7 (C-2) - sc-166031 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β7 (C-2): sc-166031. Western blot analysis of Integrin β7 expression in HeLa (A) and ECV304 (B) whole cell lysates.

Integrin β7 (C-20) - sc-6634 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin β7 (C-20): sc-6634. Western blot analysis of Integrin β7 expression in HeLa (A), ECV304 (B), Ramos (C) and K-562 (D) whole cell lysates.

Integrin β7 (N-18) - sc-6635 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin β7 (N-18): sc-6635. Western blot analysis of Integrin β7 expression in non-transfected: sc-110760 (A) and human Integrin β7 transfected: sc-173947 (B) 293 whole cell lysates.

Integrin β7 (FIB504) - sc-23919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
Integrin β7 (FIB504) PE: sc-23919 PE. FCM analysis of TK-1 cells. Black line histogram represents the isotype control, normal rat IgG<sub>2a</sub>: sc-2872.

Integrin β7 (H-120) - sc-15330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Integrin beta 7 antibody - ab198796 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Integrin beta 7 antibody (ab198796) at 1/200 dilutionLane 1 : PC3 cell lysateLane 2 : K562 cell lysateLysates/proteins at 40 µg per lane.

Anti-Integrin beta 7 antibody - ab124223 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Integrin beta 7 antibody (ab124223) at 1/100 dilution + WiDr cell lysate at 35 µg

Anti-Integrin beta 7 antibody [EP5948] - ab137058 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP5948
Overlay histogram showing Jurkat T cells stained with ab137058 (red line). Cells were incubated with the antibody at 1/100 in DMEM at 20°C for 30 minutes.The secondary antibody used was DyLight® 649 goat anti-rabbit IgG at 1/300 dilution. A non-specific IgG antibody was used for an isotype control (black line).See Abreview

Anti-Integrin beta 7 antibody [EPR1357] - ab108926 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1357
All lanes : Anti-Integrin beta 7 antibody [EPR1357] (ab108926) at 1/1000 dilutionLane 1 : Human peripheral blood mononuclear lysateLane 2 : Human tonsil lysateLane 3 : THP-1 cell lysateLysates/proteins at 10 µg per lane.

Anti-Integrin beta 7 antibody [FIB504] (Biotin) - ab95816 from Abcam

Prices $370.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone FIB504
ICC/IF image of Integrin beta 7 staining on RAW264.7 cell line using ab95816 (1:300). The cells were fixed using formaldehyde and permeabilized using 0.2% Triton X-100. The cells were blocked using 10% goat serum for 1 hour at 20°C. The cells were incubated with ab95816 (1:300) for 1 hour at 20°C. The staining was detected using Streptavedin conjugated to Alexo Fluor 647 (1:350)See Abreview

Anti-Integrin beta 7 antibody [FIB504] (FITC) - ab95818 from Abcam

Prices $370.00
Sizes 100 tests
Host Rat
Clonality Monoclonal
Clone FIB504
Staining of normal Human peripheral blood cells with Rat IgG2a ? Isotype Control FITC (open histogram) or ab95818 (filled histogram). Cells in the lymphocyte gate were used for analysis.

Anti-Integrin beta 7 antibody [FIB504] (Phycoerythrin) - ab95817 from Abcam

Prices $370.00
Sizes 100 tests
Host Rat
Clonality Monoclonal
Clone FIB504
Staining of normal Human peripheral blood cells with Rat IgG2a ? Isotype Control PE (open histogram) or ab95817 (filled histogram). Cells in the lymphocyte gate were used for analysis.

Anti-ITGB7 / Integrin Beta 7 Antibody (aa20-723) - LS-C70801 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-ITGB7 / Integrin Beta 7 Antibody - LS-C123860 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal

Anti-ITGB7 / Integrin Beta 7 Antibody (aa20-723) - LS-C125779 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ITGB7 / Integrin Beta 7 Antibody (aa22-723, Biotin) - LS-C125780 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-ITGB7 / Integrin Beta 7 Antibody (clone FIB504) - LS-C41345 from LifeSpan Bioscience

Prices $225.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone FIB504
Human peripheral blood lymphocytes stained with purified FIB504, followed by anti-mouse IgG FITC

Anti-ITGB7 / Integrin Beta 7 Antibody (clone FIB504) - LS-C190954 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone FIB504

Anti-ITGB7 / Integrin Beta 7 Antibody (aa737-765, APC) - LS-C260526 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB7 / Integrin Beta 7 Antibody (aa737-765, AP) - LS-C260527 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB7 / Integrin Beta 7 Antibody (aa737-765, Biotin) - LS-C260528 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB7 / Integrin Beta 7 Antibody (clone FIB504) - LS-C106920 from LifeSpan Bioscience

Prices $215.00, $245.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone FIB504
Staining of normal human peripheral blood cells with 0.06 ug of Purified Rat IgG2a isotype control (open histogram) or 0.06 ug of Purified anti-mouse/human integrin beta7 (FIB504) (colored histogram) followed by PE Anti-Rat IgG (LS-C106534). Cells in the lymphocyte gate were used for analysis.

Anti-ITGB7 / Integrin Beta 7 Antibody (aa737-765, FITC) - LS-C260530 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB7 / Integrin Beta 7 Antibody (aa737-765, PE) - LS-C260532 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB7 / Integrin Beta 7 Antibody (clone FIB504, PE) - LS-C105989 from LifeSpan Bioscience

Prices $205.00, $335.00
Sizes 25 tst, 100 tst
Host Rat
Clonality Monoclonal
Clone FIB504
Staining of normal human peripheral blood cells with PE Rat IgG2a isotype control (open histogram) or PE anti-mouse/human integrin beta7 (FIB504) (colored histogram). Cells in the lymphocyte gate were used for analysis.
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