ECE1
| Gene Symbol | ECE1 |
|---|---|
| Entrez Gene | 1889 |
| Alt Symbol | ECE |
| Species | Human |
| Gene Type | protein-coding |
| Description | endothelin converting enzyme 1 |
| Other Description | ECE-1|endothelin-converting enzyme 1 |
| Swissprots | Q17RN5 Q9Y501 B4E291 Q9UJQ6 P42892 Q14217 Q5THM5 Q9UPF4 A8K3P1 Q2Z2K8 Q5THM8 Q5THM7 Q58GE7 Q9UPM4 |
| Accessions | AAD08993 AAD21221 AAX35820 CAA02807 CAA63015 CAA63016 EAW94957 EAW94958 EAW94959 EAW94960 EAW94961 EAW94962 EAW94963 EAW94964 EAW94965 EAW94966 P42892 AB031742 BAA83687 AJ130828 CAB46443 AK123231 AK290656 BAF83345 AK296486 BAG59124 AK304167 BAG65053 AK309677 BC023596 BC041647 BC053342 BC063506 BC077076 BC106022 BC117256 AAI17257 BC126257 AAI26258 BP234532 BP337331 BU733112 BX648351 CN298523 CN298525 D43698 BAA07800 D49471 BAA08442 DA436879 DA445355 DA445401 DB290492 HQ258359 ADR83113 X98272 CAA66922 Z35307 CAA84548 XM_006710398 XP_006710461 XM_011540872 XP_011539174 XM_011540873 XP_011539175 NM_001113347 NP_001106818 NM_001113348 NP_001106819 NM_001113349 NP_001106820 NM_001397 NP_001388 |
| Function | Converts big endothelin-1 to endothelin-1. {ECO:0000269|PubMed:9396733}. |
| Subcellular Location | Cell membrane; Single-pass type II membrane protein. |
| Tissue Specificity | All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney. {ECO:0000269|PubMed:10491078, ECO:0000269|PubMed:9396733}. |
ECE-1 CRISPR/Cas9 KO Plasmid (h) - sc-402379 from Santa Cruz Biotechnology
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ECE-1 HDR Plasmid (h) - sc-402379-HDR from Santa Cruz Biotechnology
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ECE-1 Double Nickase Plasmid (h) - sc-402379-NIC from Santa Cruz Biotechnology
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ECE-1 Double Nickase Plasmid (h2) - sc-402379-NIC-2 from Santa Cruz Biotechnology
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ECE-1 CRISPR Activation Plasmid (h) - sc-402379-ACT from Santa Cruz Biotechnology
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ECE-1 CRISPR Activation Plasmid (h2) - sc-402379-ACT-2 from Santa Cruz Biotechnology
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ECE-1 Lentiviral Activation Particles (h) - sc-402379-LAC from Santa Cruz Biotechnology
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ECE-1 Lentiviral Activation Particles (h2) - sc-402379-LAC-2 from Santa Cruz Biotechnology
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ECE-1 siRNA (h) - sc-44478 from Santa Cruz Biotechnology
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ECE-1 shRNA Plasmid (h) - sc-44478-SH from Santa Cruz Biotechnology
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ECE-1 shRNA (h) Lentiviral Particles - sc-44478-V from Santa Cruz Biotechnology
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ECE-1 RNAi - H00001889-R01 from Novus Biologicals
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MISSION® esiRNA - EHU082101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1909 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1909 from Sigma-Aldrich
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ECE1 siRNA (Human) - CRH1315 from Cohesion Biosciences
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ECE1 - MBS8228190 from MyBioSource
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shRNA set against Human ECE1 (NM_001397.2) - SHH282841 from Creative biogene
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shRNA set against Human ECE1(NM_001397.2) - SHG209395 from Creative biogene
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ECE1 shRNA Plasmid (Human) - CHH1315 from Cohesion Biosciences
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ECE1 miRNA 3'UTR clone - MiUTR1H-03089 from Creative biogene
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