Gene Symbol | MMRN2 |
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Entrez Gene | 79812 |
Alt Symbol | EMILIN-3, EMILIN3, ENDOGLYX-1 |
Species | Human |
Gene Type | protein-coding |
Description | multimerin 2 |
Other Description | EMILIN-like protein EndoGlyx-1|elastin microfibril interface located protein 3|elastin microfibril interfacer 3|endoGlyx-1 p125/p140 subunit|multimerin-2 |
Swissprots | Q504V7 Q9H8L6 Q6P2N2 |
Accessions | EAW80319 Q9H8L6 AK023527 BAB14599 AK293822 BAG57226 AK304727 BAG65490 AK308401 BC064415 AAH64415 BC072456 BC094744 AAH94744 BM673127 DC416005 W38498 XM_005270153 XP_005270210 XM_006717970 XP_006718033 NM_024756 NP_079032 |
Function | Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. {ECO:0000269|PubMed:22020326}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11559704}. |
Tissue Specificity | Endothelium. {ECO:0000269|PubMed:11559704}. |
Multimerin-2 CRISPR/Cas9 KO Plasmid (h) - sc-405462 from Santa Cruz Biotechnology
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Multimerin-2 HDR Plasmid (h) - sc-405462-HDR from Santa Cruz Biotechnology
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Multimerin-2 Double Nickase Plasmid (h) - sc-405462-NIC from Santa Cruz Biotechnology
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Multimerin-2 Double Nickase Plasmid (h2) - sc-405462-NIC-2 from Santa Cruz Biotechnology
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Multimerin-2 CRISPR Activation Plasmid (h) - sc-405462-ACT from Santa Cruz Biotechnology
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Multimerin-2 CRISPR Activation Plasmid (h2) - sc-405462-ACT-2 from Santa Cruz Biotechnology
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Multimerin-2 Lentiviral Activation Particles (h) - sc-405462-LAC from Santa Cruz Biotechnology
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Multimerin-2 Lentiviral Activation Particles (h2) - sc-405462-LAC-2 from Santa Cruz Biotechnology
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Multimerin-2 siRNA (h) - sc-75844 from Santa Cruz Biotechnology
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Multimerin-2 shRNA Plasmid (h) - sc-75844-SH from Santa Cruz Biotechnology
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Multimerin-2 shRNA (h) Lentiviral Particles - sc-75844-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU031041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14440 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14440 from Sigma-Aldrich
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MMRN2 siRNA (Human) - CRJ2582 from Cohesion Biosciences
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shRNA set against Human MMRN2 (NM_024756.2) - SHH343152 from Creative biogene
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MMRN2 shRNA Plasmid (Human) - CHJ2582 from Cohesion Biosciences
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MMRN2 miRNA 3'UTR clone - MiUTR3H-10307 from Creative biogene
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