HYAL1
| Gene Symbol | HYAL1 |
|---|---|
| Entrez Gene | 3373 |
| Alt Symbol | HYAL-1, LUCA1, MPS9, NAT6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | hyaluronoglucosaminidase 1 |
| Other Description | hyaluronidase-1|luCa-1|lung carcinoma protein 1|plasma hyaluronidase|tumor suppressor LUCA-1 |
| Swissprots | Q8NFK6 Q12794 Q7KYU2 Q9UNI8 Q8NFK5 Q7LE34 Q93013 Q6FH23 Q9UKD5 Q8NFK8 Q6PIZ6 Q8NFK9 Q8NFK7 |
| Accessions | AAB67046 AAC02730 EAW65083 EAW65084 EAW65085 EAW65086 EAW65087 EAW65088 EAW65089 EAW65090 EAW65091 Q12794 AF118821 AAD24460 AF173154 AAD53277 AF502904 AAM60770 AF502905 AAM60771 AF502906 AAM60772 AF502907 AAM60773 AF502908 AAM60774 AK097287 BAG53447 AK290816 BAF83505 BC025774 AAH25774 BC035695 AAH35695 CR541933 CAG46731 DA566755 DQ894083 ABM85009 EU176527 ABW03328 U03056 AAD09137 U96078 AAD04190 XM_011533667 XP_011531969 XM_011533668 XP_011531970 XM_011533669 XP_011531971 NM_033159 NP_149349 NM_153281 NP_695013 NM_153282 NP_695014 NM_153283 NP_695015 NM_153285 NP_695017 NR_047690 NM_153284 NM_153286 |
| Function | May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. {ECO:0000269|PubMed:12084718}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:9223416}. Lysosome {ECO:0000269|PubMed:9223416}. |
| Tissue Specificity | Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. {ECO:0000269|PubMed:10339581, ECO:0000269|PubMed:12084718, ECO:0000269|PubMed:9223416}. |
| Top Pathways | Lysosome, Glycosaminoglycan degradation |
HYAL1 CRISPR/Cas9 KO Plasmid (h) - sc-404500 from Santa Cruz Biotechnology
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HYAL1 HDR Plasmid (h) - sc-404500-HDR from Santa Cruz Biotechnology
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HYAL1 Double Nickase Plasmid (h) - sc-404500-NIC from Santa Cruz Biotechnology
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HYAL1 Double Nickase Plasmid (h2) - sc-404500-NIC-2 from Santa Cruz Biotechnology
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HYAL1 CRISPR Activation Plasmid (h) - sc-404500-ACT from Santa Cruz Biotechnology
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HYAL1 CRISPR Activation Plasmid (h2) - sc-404500-ACT-2 from Santa Cruz Biotechnology
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HYAL1 Lentiviral Activation Particles (h) - sc-404500-LAC from Santa Cruz Biotechnology
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HYAL1 Lentiviral Activation Particles (h2) - sc-404500-LAC-2 from Santa Cruz Biotechnology
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HYAL1 siRNA (h) - sc-78054 from Santa Cruz Biotechnology
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HYAL1 shRNA Plasmid (h) - sc-78054-SH from Santa Cruz Biotechnology
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HYAL1 shRNA (h) Lentiviral Particles - sc-78054-V from Santa Cruz Biotechnology
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Hyaluronidase 1/HYAL1 RNAi - H00003373-R11 from Novus Biologicals
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FUS2 RNAi - H00024142-R01 from Novus Biologicals
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Hyaluronidase 1/HYAL1 RNAi - H00003373-R09 from Novus Biologicals
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Hyaluronidase 1/HYAL1 RNAi - H00003373-R15 from Novus Biologicals
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Hyaluronidase 1/HYAL1 RNAi - H00003373-R16 from Novus Biologicals
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Hyaluronidase 1/HYAL1 RNAi - H00003373-R12 from Novus Biologicals
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Hyaluronidase 1/HYAL1 RNAi - H00003373-R13 from Novus Biologicals
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MISSION® esiRNA - EHU074821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10410 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10410 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05044 from Sigma-Aldrich
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HYAL1 siRNA (Human) - CRH2296 from Cohesion Biosciences
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Hyaluronidase 1/HYAL1 RNAi - H00003373-R14 from Novus Biologicals
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Hyaluronidase 1/HYAL1 RNAi - H00003373-R10 from Novus Biologicals
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