| Gene Symbol |
PPID
|
| Entrez Gene |
5481
|
| Alt Symbol |
CYP-40, CYPD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peptidylprolyl isomerase D
|
| Other Description |
40 kDa peptidyl-prolyl cis-trans isomerase D|PPIase D|cyclophilin 40|cyclophilin D|cyclophilin-40|cyclophilin-related protein|peptidyl-prolyl cis-trans isomerase D|rotamase D
|
| Swissprots |
B2R9V2 Q08752
|
| Accessions |
AAG43201 AAT97986 ADP90614 ADP90615 ADP90616 ADP90617 ADP90618 ADP90619 ADP90620 ADP90621 ADP90622 ADP90623 ADP90624 ADP90625 ADP90626 ADP90627 ADP90628 ADP90629 ADP90630 ADP90631 ADP90632 ADP90633 ADP90634 ADP90635 ADP90636 ADP90637 ADP90638 ADP90639 ADP90640 ADP90641 ADP90642 ADP90643 ADP90644 ADP90645 ADP90646 ADP90647 ADP90648 ADP90649 ADP90650 ADP90651 ADP90652 ADP90653 BAA09923 EAX04853 Q08752 AK313929 BAG36649 BC014893 AAH14893 BC030707 AAH30707 BG699755 BU726810 CR542081 CAG46878 DQ891562 ABM82488 DQ894749 ABM85675 L11667 AAA35731 NM_005038 NP_005029
|
| Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-po
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
|
| Tissue Specificity |
Widely expressed.
|
![Western Blot: Cyclophilin 40 Overexpression Lysate (Adult Normal) [NBL1-14648] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cyclophilin 40.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/873_Cyclophilin%252040%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14648-img0002.jpg)