Gene Symbol | PPID |
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Entrez Gene | 5481 |
Alt Symbol | CYP-40, CYPD |
Species | Human |
Gene Type | protein-coding |
Description | peptidylprolyl isomerase D |
Other Description | 40 kDa peptidyl-prolyl cis-trans isomerase D|PPIase D|cyclophilin 40|cyclophilin D|cyclophilin-40|cyclophilin-related protein|peptidyl-prolyl cis-trans isomerase D|rotamase D |
Swissprots | B2R9V2 Q08752 |
Accessions | AAG43201 AAT97986 ADP90614 ADP90615 ADP90616 ADP90617 ADP90618 ADP90619 ADP90620 ADP90621 ADP90622 ADP90623 ADP90624 ADP90625 ADP90626 ADP90627 ADP90628 ADP90629 ADP90630 ADP90631 ADP90632 ADP90633 ADP90634 ADP90635 ADP90636 ADP90637 ADP90638 ADP90639 ADP90640 ADP90641 ADP90642 ADP90643 ADP90644 ADP90645 ADP90646 ADP90647 ADP90648 ADP90649 ADP90650 ADP90651 ADP90652 ADP90653 BAA09923 EAX04853 Q08752 AK313929 BAG36649 BC014893 AAH14893 BC030707 AAH30707 BG699755 BU726810 CR542081 CAG46878 DQ891562 ABM82488 DQ894749 ABM85675 L11667 AAA35731 NM_005038 NP_005029 |
Function | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-po |
Subcellular Location | Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. |
Tissue Specificity | Widely expressed. |
Cyclophilin 40 (C-11) - sc-137216 from Santa Cruz Biotechnology
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Cyclophilin 40 (C-14) - sc-33068 from Santa Cruz Biotechnology
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Cyclophilin 40 (F-5) - sc-137157 from Santa Cruz Biotechnology
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Cyclophilin 40 (N-12) - sc-33066 from Santa Cruz Biotechnology
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Cyclophilin 40 (H-185) - sc-66848 from Santa Cruz Biotechnology
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Cyclophilin 40 (H-8) - sc-137136 from Santa Cruz Biotechnology
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Anti-Cyclophilin 40 antibody - ab119489 from Abcam
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Anti-Cyclophilin 40 antibody [EPR14844] - N-terminal - ab186727 from Abcam
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Anti-Cyclophilin 40 antibody [EPR14845(B)] - ab181983 from Abcam
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Anti-PPID antibody - ab167513 from Abcam
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Anti-PPID antibody - N-terminal - ab135717 from Abcam
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Anti-PPID / Cyclophilin D Antibody (clone 4C7) IHC-plus⢠- LS-B10440 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody (aa71-120) IHC-plus⢠- LS-B5870 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody (aa356-370) - LS-C64144 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody (aa9-189, Biotin) - LS-C298839 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody (aa7-191, Biotin) - LS-C298840 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody (aa7-206, Biotin) - LS-C299527 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody (aa9-189, FITC) - LS-C302413 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody (aa7-191, FITC) - LS-C302415 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody (aa7-206, FITC) - LS-C303884 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody - LS-C307161 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody - LS-C310072 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody - LS-C310071 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody (aa179-228) - LS-C111939 from LifeSpan Bioscience
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Anti-PPID / Cyclophilin D Antibody (aa9-189) - LS-C293605 from LifeSpan Bioscience
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