| Gene Symbol |
OLIG1
|
| Entrez Gene |
116448
|
| Alt Symbol |
BHLHB6, BHLHE21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
oligodendrocyte transcription factor 1
|
| Other Description |
basic domain, helix-loop-helix protein, class B, 6|class B basic helix-loop-helix protein 6|class E basic helix-loop-helix protein 21|oligo1|oligodendrocyte lineage transcription factor 1|oligodendrocyte-specific bHLH transcription factor 1
|
| Swissprots |
Q7RTS0 Q8TAK6
|
| Accessions |
EAX09848 Q8TAK6 AB209791 BAD93028 AL355743 AL834450 CAD39110 AW298788 BC011252 BC026989 AAH26989 BC033290 AAH33290 BK000278 DAA01058 DQ896828 ABM87827 NM_138983 NP_620450
|
| Function |
Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}.
|
| Tissue Specificity |
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable. {ECO:0000269|PubMed:11526205}.
|