Gene Symbol | OLIG1 |
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Entrez Gene | 116448 |
Alt Symbol | BHLHB6, BHLHE21 |
Species | Human |
Gene Type | protein-coding |
Description | oligodendrocyte transcription factor 1 |
Other Description | basic domain, helix-loop-helix protein, class B, 6|class B basic helix-loop-helix protein 6|class E basic helix-loop-helix protein 21|oligo1|oligodendrocyte lineage transcription factor 1|oligodendrocyte-specific bHLH transcription factor 1 |
Swissprots | Q7RTS0 Q8TAK6 |
Accessions | EAX09848 Q8TAK6 AB209791 BAD93028 AL355743 AL834450 CAD39110 AW298788 BC011252 BC026989 AAH26989 BC033290 AAH33290 BK000278 DAA01058 DQ896828 ABM87827 NM_138983 NP_620450 |
Function | Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. |
Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable. {ECO:0000269|PubMed:11526205}. |
OLIG1 CRISPR/Cas9 KO Plasmid (h) - sc-402725 from Santa Cruz Biotechnology
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OLIG1 HDR Plasmid (h) - sc-402725-HDR from Santa Cruz Biotechnology
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OLIG1 Double Nickase Plasmid (h) - sc-402725-NIC from Santa Cruz Biotechnology
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OLIG1 Double Nickase Plasmid (h2) - sc-402725-NIC-2 from Santa Cruz Biotechnology
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OLIG1 CRISPR Activation Plasmid (h) - sc-402725-ACT from Santa Cruz Biotechnology
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OLIG1 CRISPR Activation Plasmid (h2) - sc-402725-ACT-2 from Santa Cruz Biotechnology
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OLIG1 Lentiviral Activation Particles (h) - sc-402725-LAC from Santa Cruz Biotechnology
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OLIG1 Lentiviral Activation Particles (h2) - sc-402725-LAC-2 from Santa Cruz Biotechnology
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OLIG1 siRNA (h) - sc-91434 from Santa Cruz Biotechnology
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OLIG1 shRNA Plasmid (h) - sc-91434-SH from Santa Cruz Biotechnology
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OLIG1 shRNA (h) Lentiviral Particles - sc-91434-V from Santa Cruz Biotechnology
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Olig1 RNAi - H00116448-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN15722 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15722 from Sigma-Aldrich
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OLIG1 siRNA (Human) - CRJ4519 from Cohesion Biosciences
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shRNA set against Human OLIG1 (NM_138983.2) - SHH361632 from Creative biogene
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Human OLIG1 siRNA - orb275020 from Biorbyt
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OLIG1 shRNA Plasmid (Human) - CHJ4519 from Cohesion Biosciences
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OLIG1 miRNA 3'UTR clone - MiUTR3H-08412 from Creative biogene
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