PSMA1
| Gene Symbol | PSMA1 |
|---|---|
| Entrez Gene | 5682 |
| Alt Symbol | HC2, HEL-S-275, NU, PROS30 |
| Species | Human |
| Gene Type | protein-coding |
| Description | proteasome (prosome, macropain) subunit, alpha type, 1 |
| Other Description | 30 kDa prosomal protein|PROS-30|epididymis secretory protein Li 275|macropain subunit C2|macropain subunit nu|multicatalytic endopeptidase complex subunit C2|proteasome component C2|proteasome nu chain|proteasome subunit alpha type-1|proteasome subunit nu|proteasome subunit, alpha-type, 1|protein P30-33K |
| Swissprots | Q9BRV9 A8K400 P25786 Q53YE8 |
| Accessions | CBF59411 CBU84655 EAW68476 EAW68477 EAW68478 EAW68479 P25786 AK290765 BAF83454 AK303565 BAG64588 AW015660 BC002577 AAH02577 BC005932 AAH05932 BC008472 AAH08472 BC009576 AAH09576 BC015105 AAH15105 BC015356 AAH15356 BC022372 AAH22372 BT006647 AAP35293 D00759 BAA00656 DA549688 DQ894660 ABM85586 FJ224300 ACI45992 M64992 AAA92734 X61969 CAA43961 NM_001143937 NP_001137409 NM_002786 NP_002777 NM_148976 NP_683877 |
| Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Nucleus. |
| Top Pathways | Proteasome |
20S Proteasome α1 CRISPR/Cas9 KO Plasmid (h) - sc-401845 from Santa Cruz Biotechnology
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20S Proteasome α1 HDR Plasmid (h) - sc-401845-HDR from Santa Cruz Biotechnology
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20S Proteasome α1 Double Nickase Plasmid (h) - sc-401845-NIC from Santa Cruz Biotechnology
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20S Proteasome α1 Double Nickase Plasmid (h2) - sc-401845-NIC-2 from Santa Cruz Biotechnology
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20S Proteasome α1 CRISPR Activation Plasmid (h) - sc-401845-ACT from Santa Cruz Biotechnology
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20S Proteasome α1 CRISPR Activation Plasmid (h2) - sc-401845-ACT-2 from Santa Cruz Biotechnology
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20S Proteasome α1 Lentiviral Activation Particles (h) - sc-401845-LAC from Santa Cruz Biotechnology
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20S Proteasome α1 Lentiviral Activation Particles (h2) - sc-401845-LAC-2 from Santa Cruz Biotechnology
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20S Proteasome α1 siRNA (h) - sc-45256 from Santa Cruz Biotechnology
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20S Proteasome α1 shRNA Plasmid (h) - sc-45256-SH from Santa Cruz Biotechnology
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20S Proteasome α1 shRNA (h) Lentiviral Particles - sc-45256-V from Santa Cruz Biotechnology
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Proteasome 20S C2 RNAi - H00005682-R01V from Novus Biologicals
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Proteasome 20S C2 RNAi - H00005682-R01 from Novus Biologicals
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MISSION® esiRNA - EHU140871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17588 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17588 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03014 from Sigma-Aldrich
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PSMA1 siRNA (Human) - CRH3829 from Cohesion Biosciences
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Proteasome 20S C2 RNAi - H00005682-R02 from Novus Biologicals
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shRNA set against Human PSMA1 (NM_002786.3) - SHH385040 from Creative biogene
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Human PSMA1 siRNA - orb264331 from Biorbyt
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PSMA1 shRNA Plasmid (Human) - CHH3829 from Cohesion Biosciences
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PSMA1 miRNA 3'UTR clone - MiUTR3H-05350 from Creative biogene
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PSMA1 miRNA 3'UTR clone - MiUTR3H-05351 from Creative biogene
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PSMA1 miRNA 3'UTR clone - MiUTR3H-05352 from Creative biogene
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