PSMA1

Gene Symbol PSMA1
Entrez Gene 5682
Alt Symbol HC2, HEL-S-275, NU, PROS30
Species Human
Gene Type protein-coding
Description proteasome (prosome, macropain) subunit, alpha type, 1
Other Description 30 kDa prosomal protein|PROS-30|epididymis secretory protein Li 275|macropain subunit C2|macropain subunit nu|multicatalytic endopeptidase complex subunit C2|proteasome component C2|proteasome nu chain|proteasome subunit alpha type-1|proteasome subunit nu|proteasome subunit, alpha-type, 1|protein P30-33K
Swissprots Q9BRV9 A8K400 P25786 Q53YE8
Accessions CBF59411 CBU84655 EAW68476 EAW68477 EAW68478 EAW68479 P25786 AK290765 BAF83454 AK303565 BAG64588 AW015660 BC002577 AAH02577 BC005932 AAH05932 BC008472 AAH08472 BC009576 AAH09576 BC015105 AAH15105 BC015356 AAH15356 BC022372 AAH22372 BT006647 AAP35293 D00759 BAA00656 DA549688 DQ894660 ABM85586 FJ224300 ACI45992 M64992 AAA92734 X61969 CAA43961 NM_001143937 NP_001137409 NM_002786 NP_002777 NM_148976 NP_683877
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Nucleus.
Top Pathways Proteasome

20S Proteasome α1 (H-95) - sc-67046 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
20S Proteasome α1 (H-95): sc-67046. Western blot analysis of 20S Proteasome α1 expression in non-transfected: sc-117752 (A) and mouse 20S Proteasome α1 transfected: sc-127386 (B) 293T whole cell lysates.

20S Proteasome α1 (G-13) - sc-34126 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
20S Proteasome α1 (G-13): sc-34126. Western blot analysis of 20S Proteasome α1 expression in HeLa (A), Hep G2 (B), c4 (C) and MIA PaCa-2 (D) whole cell lysates.

20S Proteasome α1 (C-7) - sc-166073 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
20S Proteasome α1 (C-7): sc-166073. Western blot analysis of 20S Proteasome α11 expression in non-transfected: sc-117752 (A) and human 20S Proteasome α11 transfected: sc-112756 (B) 293T whole cell lysates.

20S Proteasome α1/α2/α3/α5/α6/α7 (MCP231) - sc-58412 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
20S Proteasome α1/α2/α3/α5/α6/α7 (MCP231): sc-58412. Western blot analysis of 20S Proteasomeα 5 expression in non-transfected 293T: sc-117752 (A), human 20S Proteasomeα 5 transfected 293T: sc-111717 (B) and HeLa (C) whole cell lysates.

Anti-Proteasome 20S alpha 1+2+3+5+6+7 antibody [MCP231] - ab22674 from Abcam

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone MCP231
ICC/IF image of ab22674 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab22674, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-mouse IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Proteasome 20S C2 antibody - ab123358 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Proteasome 20S C2 antibody (ab123358) at 1/100 dilution + A2058 cell line lysate at 35 µg

Anti-Proteasome 20S C2 antibody [EPR5451] - ab109500 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5451
All lanes : Anti-Proteasome 20S C2 antibody [EPR5451] (ab109500) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLane 3 : HepG2 cell lysateLane 4 : PC-3 cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Proteasome 20S C2 antibody [EPR5452] - ab109530 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5452
All lanes : Anti-Proteasome 20S C2 antibody [EPR5452] (ab109530) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysateLane 3 : HepG2 cell lysateLane 4 : PC3 cell lysatesLysates/proteins at 10 µg per lane.

Anti-Proteasome 20S C2 antibody [MCP20] - ab22665 from Abcam

Prices $388.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone MCP20
Overlay histogram showing HeLa cells stained with ab22665 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab22665, 1/100 dilution) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.

Anti-PSMA1 Antibody (C-Terminus) - LS-C89599 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PSMA1 Antibody (aa16-263) - LS-C182937 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-PSMA1 Antibody (aa233-262, AP) - LS-C267272 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMA1 Antibody (N-Terminus) - LS-C31540 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-PSMA1 Antibody (aa233-262, APC) - LS-C267273 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMA1 Antibody (aa233-262, Biotin) - LS-C267274 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMA1 Antibody (aa233-262, FITC) - LS-C267275 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMA1 Antibody (aa233-262, Azide-free, HRP) - LS-C267276 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMA1 Antibody (aa233-262, PE) - LS-C267277 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMA1 Antibody (aa233-262) - LS-C324353 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PSMA1 Antibody - LS-C341427 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PSMA1 Antibody (clone 3D8) - LS-C139348 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D8
Detection limit for recombinant GST tagged PSMA1 is approximately 3 ng/ml as a capture antibody.

Anti-PSMA1 Antibody (clone 3F12-2C9) - LS-C139349 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F12-2C9
Detection limit for recombinant GST tagged PSMA1 is approximately 3 ng/ml as a capture antibody.

Anti-PSMA1 Antibody (Internal, clone EPR5451) - LS-C138406 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5451
IHC of paraffin-embedded human breast tissue using anti-PSMA1 antibody.

Anti-PSMA1 Antibody (aa163-213) - LS-C290494 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PSMA1 by Western Blot. Samples: Whole cell lysate from 293T (15 and 50 ug), HeLa (H; 50 ug), and Jurkat (J; 50 ug) cells. Antibodies: Affinity purified rabbit anti-PSMA1 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-PSMA1 Antibody (aa233-262) - LS-C162215 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PSMA1 Antibody western blot of A2058 cell line lysates (35 ug/lane). The PSMA1 antibody detected the PSMA1 protein (arrow).
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