| Gene Symbol |
C1orf86
|
| Entrez Gene |
199990
|
| Alt Symbol |
FAAP20, FP7162
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromosome 1 open reading frame 86
|
| Other Description |
Fanconi anemia-associated protein of 20 kDa
|
| Swissprots |
F2Z2L4 A6PW40 Q6NZ36 Q96ND7 A8MQT6 Q6ZT64 Q71M24 A6PW39 A6PW41
|
| Accessions |
EAW56125 EAW56126 EAW56127 EAW56128 EAW56129 Q6NZ36 AF461903 AAQ04817 AF469129 AAP97719 AK054818 AK055593 BAB70965 AK093927 BAC04254 AK125445 AK126870 BAC86730 AK127994 BAC87220 AK128507 AL545931 BC041041 BC066360 AAH66360 BC078145 BC103992 AAI03993 BG825658 BM127377 BM674927 BM682341 BU192678 BU542153 BU626113 CN397640 DA596011 XM_006710419 XP_006710482 XM_006710420 XP_006710483 XM_006710421 XP_006710484 XM_011540914 XP_011539216 XM_011540915 XP_011539217 XM_011540916 XP_011539218 XM_011540917 XP_011539219 XM_011540918 XP_011539220 XM_011540919 XP_011539221 XM_011540920 XP_011539222 XM_011540921 XP_011539223 XM_011540922 XP_011539224 NR_024445 NM_001146310 NP_001139782 NM_001256945 NP_001243874 NM_001256946 NP_001243875 NM_001256947 NP_001243876 NM_001282670 NP_001269599 NM_001282671 NP_001269600 NM_001282672 NP_001269601 NM_001282673 NP_001269602 NM_182533 NP_872339 NR_046427
|
| Function |
Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. {ECO:0000269|PubMed:22266823, ECO:0000269|PubMed:22343915, ECO:0000269|PubMed:22396592, ECO:0000269|PubMed:22705371}.
|
| Subcellular Location |
Nucleus. Chromosome. Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8.
|
