OLR1
| Gene Symbol | OLR1 |
|---|---|
| Entrez Gene | 4973 |
| Alt Symbol | CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | oxidized low density lipoprotein (lectin-like) receptor 1 |
| Other Description | C-type lectin domain family 8 member A|hLOX-1|lectin-type oxidized LDL receptor 1|ox LDL receptor 1|oxidized low-density lipoprotein receptor 1|oxidized low-density lipoprotein receptor 1, soluble form|scavenger receptor class E, member 1 |
| Swissprots | Q2PP00 Q7Z484 A8K7V9 P78380 B4DI48 G3V1I4 |
| Accessions | AAC97927 ABC40744 CAB38175 CAL68889 CCQ77677 EAW96156 EAW96157 EAW96158 EAW96159 P78380 AB010710 BAA24580 AB102861 BAC81565 AF035776 AAC82329 AK292124 BAF84813 AK295409 BAG58360 AK298040 BAG60339 AK308009 AK316353 BAH14724 AL551100 BC022295 AAH22295 BC055085 BP219342 BQ028409 CA309323 CB955704 DQ891409 ABM82335 DQ894585 ABM85511 XM_011520682 XP_011518984 XM_011520683 XP_011518985 NM_001172632 NP_001166103 NM_001172633 NP_001166104 NM_002543 NP_002534 |
| Function | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for |
| Subcellular Location | Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation. |
| Tissue Specificity | Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. {ECO:0000269|PubMed:12354387, ECO:0000269|PubMed:9052782, ECO:0000269|PubMed:9828121}. |
| Top Pathways | PPAR signaling pathway, Phagosome |
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