OLR1

Gene Symbol OLR1
Entrez Gene 4973
Alt Symbol CLEC8A, LOX1, LOXIN, SCARE1, SLOX1
Species Human
Gene Type protein-coding
Description oxidized low density lipoprotein (lectin-like) receptor 1
Other Description C-type lectin domain family 8 member A|hLOX-1|lectin-type oxidized LDL receptor 1|ox LDL receptor 1|oxidized low-density lipoprotein receptor 1|oxidized low-density lipoprotein receptor 1, soluble form|scavenger receptor class E, member 1
Swissprots Q2PP00 Q7Z484 A8K7V9 P78380 B4DI48 G3V1I4
Accessions AAC97927 ABC40744 CAB38175 CAL68889 CCQ77677 EAW96156 EAW96157 EAW96158 EAW96159 P78380 AB010710 BAA24580 AB102861 BAC81565 AF035776 AAC82329 AK292124 BAF84813 AK295409 BAG58360 AK298040 BAG60339 AK308009 AK316353 BAH14724 AL551100 BC022295 AAH22295 BC055085 BP219342 BQ028409 CA309323 CB955704 DQ891409 ABM82335 DQ894585 ABM85511 XM_011520682 XP_011518984 XM_011520683 XP_011518985 NM_001172632 NP_001166103 NM_001172633 NP_001166104 NM_002543 NP_002534
Function Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for
Subcellular Location Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation.
Tissue Specificity Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. {ECO:0000269|PubMed:12354387, ECO:0000269|PubMed:9052782, ECO:0000269|PubMed:9828121}.
Top Pathways PPAR signaling pathway, Phagosome

Ox-LDL R-1 (N-14) - sc-11648 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ox-LDL R-1 (N-14): sc-11648. Western blot analysis of Ox-LDL R-1 expression in mouse heart tissue extract.

Ox-LDL R-1 (E-19) - sc-11650 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Ox-LDL R-1 (H-140) - sc-20753 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Ox-LDL R-1 (LOX19-22) - sc-66155 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Ox-LDL R-1 (LOX19-22): sc-66155. Western blot analysis of Ox-LDL R-1 expression in human coronary vessels.

Anti-LOX 1 antibody - ab60178 from Abcam

Prices $390.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LOX 1 antibody (ab60178) at 0.5 µg/mlLane 1 : Jurkat cell lysateLane 2 : Jurkat cell lysate

Anti-LOX 1 antibody - ab126538 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of LOX 1 staining in human kidney formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab126538, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-LOX 1 antibody - ab65864 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab65864 stained JEG-3 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab65864, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-LOX 1 antibody - ab191363 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LOX 1 antibody - ab111747 from Abcam

Host Sheep
Clonality Polyclonal

Anti-LOX 1 antibody [23C11] - ab81709 from Abcam

Prices $382.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 23C11
Human spleen cells stained for LOX-1 immunolocalization (200x). Immunohistochemical staining of frozen sections with antibody 23C11

Anti-LOX 1 antibody [23C11] (FITC) - ab81710 from Abcam

Prices $382.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 23C11
Overlay histogram showing A549 cells stained with ab81710 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab81710, 0.5µg/1x106 cells) for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 FITC (1µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-LOX 1 antibody [23C11] - BSA free - ab175558 from Abcam

Prices $7,759.00
Sizes 1 mg
Host Mouse
Clonality Monoclonal
Clone 23C11

Anti-LOX 1 antibody [B017M] - ab130882 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone B017M

Anti-LOX 1 antibody [B019M] - ab130871 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone B019M

Anti-LOX 1 antibody [LOX19-22] - ab53202 from Abcam

Prices $370.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone LOX19-22

Anti-LOX 1 antibody - C-terminal - ab203246 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded rat aorta tissue labeling LOX 1 with ab203246 at 1/100 dilution, followed by conjugation to the secondary antibody and DAB staining.

LOX-1/OLR1 Antibody [Unconjugated] - AF1798 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
LOX‑1/OLR1 was detected in immersion fixed paraffin-embedded sections of human placenta using Goat Anti-Human LOX‑1/OLR1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1798) at 1 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to cytotrophoblasts. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

LOX-1/OLR1 Antibody (331212) [Unconjugated] - MAB1798 from Novus Biologicals

Prices $99.00, $259.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 331212

LOX-1/OLR1 Antibody - NBP2-27298 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

LOX-1/OLR1 Antibody (LOX20-4) - NB110-59910 from Novus Biologicals

Prices $199.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone LOX20-4

LOX-1/OLR1 Antibody (LOX19-22) - NB110-79871 from Novus Biologicals

Prices $199.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone LOX19-22

LOX-1/OLR1 Antibody [Biotin] - BAF1798 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

LOX-1/OLR1 Antibody (331212) [Phycoerythrin] - FAB1798P from Novus Biologicals

Prices $299.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 331212
THP-1 human acute monocytic leukemia cell line either untreated (filled histogram) or treated with 50 ng/mL PMA for 3 days (open histogram) was stained with Mouse Anti-Human LOX-1/OLR1 PE-conjugated Monoclonal Antibody (Catalog # FAB1798P) or isotype control antibody (Catalog # IC0041P). View our protocol for Staining Membrane-associated Proteins.

LOX-1/OLR1 Antibody (331212) [Alexa Fluor 488] - FAB1798G from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 331212
THP-1 human acute monocytic leukemia cell line either untreated (light orange filled histogram) or treated with 50 ng/mL PMA for 3 days (dark orange filled histogram) was stained with Mouse Anti-Human LOX-1/OLR1 Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB1798G) or isotype control antibody (Catalog # IC0041G, open histogram). View our protocol for Staining Membrane-associated Proteins.

LOX-1/OLR1 Antibody (331212) [PerCP] - FAB1798C from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 331212
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