| Gene Symbol |
Eif4ebp1
|
| Entrez Gene |
13685
|
| Alt Symbol |
4e-bp1, AA959816, PHAS-I
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 4E binding protein 1
|
| Other Description |
eIF4E-binding protein 1|eukaryotic translation initiation factor 4E-binding protein 1|phosphorylated heat- and acid-stable protein regulated by insulin 1
|
| Swissprots |
Q9CZ40 Q60876 Q3TDS8
|
| Accessions |
EDL32790 Q60876 AK013033 BAB28612 AK167836 BAE39857 AK169979 BAE41494 AK170031 BAE41521 AK192788 BC002045 AAH02045 BE651550 BY318447 U28656 AAA88818 NM_007918 NP_031944
|
| Function |
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7629182). {ECO:0000250|UniProtKB:Q13541, ECO:0000269|PubMed:7629182}.
|
| Tissue Specificity |
Highest expression in fat cells. {ECO:0000269|PubMed:7629182}.
|
| Top Pathways |
RNA transport, Choline metabolism in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway, ErbB signaling pathway
|