Eif4ebp1

Gene Symbol	Eif4ebp1
Entrez Gene	13685
Alt Symbol	4e-bp1, AA959816, PHAS-I
Species	Mouse
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 4E binding protein 1
Other Description	eIF4E-binding protein 1|eukaryotic translation initiation factor 4E-binding protein 1|phosphorylated heat- and acid-stable protein regulated by insulin 1
Swissprots	Q9CZ40 Q60876 Q3TDS8
Accessions	EDL32790 Q60876 AK013033 BAB28612 AK167836 BAE39857 AK169979 BAE41494 AK170031 BAE41521 AK192788 BC002045 AAH02045 BE651550 BY318447 U28656 AAA88818 NM_007918 NP_031944
Function	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7629182). {ECO:0000250|UniProtKB:Q13541, ECO:0000269|PubMed:7629182}.
Tissue Specificity	Highest expression in fat cells. {ECO:0000269|PubMed:7629182}.
Top Pathways	RNA transport, Choline metabolism in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® 4E-BP1 siRNA II (Mouse Specific) - 6393 from Cell Signaling Technology Category siRNA

SignalSilence ® 4E-BP1 siRNA I (Mouse Specific) - 6392 from Cell Signaling Technology Category siRNA

4E-BP1 CRISPR/Cas9 KO Plasmid (m) - sc-420149 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

4E-BP1 HDR Plasmid (m) - sc-420149-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

4E-BP1 Double Nickase Plasmid (m) - sc-420149-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

4E-BP1 Double Nickase Plasmid (m2) - sc-420149-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

4E-BP1 CRISPR Activation Plasmid (m) - sc-420149-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

4E-BP1 CRISPR Activation Plasmid (m2) - sc-420149-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

4E-BP1 Lentiviral Activation Particles (m) - sc-420149-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

4E-BP1 Lentiviral Activation Particles (m2) - sc-420149-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

4E-BP1 siRNA (m) - sc-29595 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

4E-BP1 shRNA Plasmid (m) - sc-29595-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

4E-BP1 shRNA (m) Lentiviral Particles - sc-29595-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU029571 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN30559 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30559 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

EIF4EBP1 siRNA (Mouse) - CRM1173 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

EIF4EBP1 - MBS8212875 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse EIF4EBP1 (NM_007918.3) - SHH284685 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Eif4ebp1(NM_007918.3) - SHH029873 from Creative biogene Category siRNA Species Reactivities Mouse

4E-BP1 CRISPR/Cas9 KO Plasmid (m2) - sc-420149-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

4E-BP1 HDR Plasmid (m2) - sc-420149-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

Mouse EIF4EBP1 siRNA - orb280649 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

EIF4EBP1 shRNA Plasmid (Mouse) - CHM1173 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

EIF4EBP1 miRNA 3'UTR clone - MiUTR1M-04337 from Creative biogene Species Reactivities Mouse

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