| Gene Symbol | HAUS1 |
|---|---|
| Entrez Gene | 115106 |
| Alt Symbol | CCDC5, HEI-C, HEIC, HsT1461 |
| Species | Human |
| Gene Type | protein-coding |
| Description | HAUS augmin-like complex, subunit 1 |
| Other Description | HAUS augmin-like complex subunit 1|coiled-coil domain containing 5 (spindle associated)|coiled-coil domain-containing protein 5|enhancer of invasion-cluster |
| Swissprots | Q8N837 B2RDM7 Q96CS2 |
| Accessions | EAX01469 Q96CS2 AK024747 AK097403 BAC05036 AK315605 BAG37974 AY360137 AAQ63649 BC005958 AAH05958 BC014003 AAH14003 NM_138443 NP_612452 NR_026978 |
| Function | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:15082789, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the mitotic asters and is highly punctate on the microtubule array. During later stages of mitosis, remains on the spindle but is not present at the interzone, and is finally observed at the microtubule bundles proximal to the midbody, clearly excluded from the midbody. In contrast, does not colocalize with the tubulin cytoskeleton in interphase cells. In interphase, localized at the centrosome and diffusely in the cytoplasm. |
| Tissue Specificity | Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly expressed in lung, brain and placenta. {ECO:0000269|PubMed:15082789}. |