Gene Symbol | HAUS1 |
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Entrez Gene | 115106 |
Alt Symbol | CCDC5, HEI-C, HEIC, HsT1461 |
Species | Human |
Gene Type | protein-coding |
Description | HAUS augmin-like complex, subunit 1 |
Other Description | HAUS augmin-like complex subunit 1|coiled-coil domain containing 5 (spindle associated)|coiled-coil domain-containing protein 5|enhancer of invasion-cluster |
Swissprots | Q8N837 B2RDM7 Q96CS2 |
Accessions | EAX01469 Q96CS2 AK024747 AK097403 BAC05036 AK315605 BAG37974 AY360137 AAQ63649 BC005958 AAH05958 BC014003 AAH14003 NM_138443 NP_612452 NR_026978 |
Function | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:15082789, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the mitotic asters and is highly punctate on the microtubule array. During later stages of mitosis, remains on the spindle but is not present at the interzone, and is finally observed at the microtubule bundles proximal to the midbody, clearly excluded from the midbody. In contrast, does not colocalize with the tubulin cytoskeleton in interphase cells. In interphase, localized at the centrosome and diffusely in the cytoplasm. |
Tissue Specificity | Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly expressed in lung, brain and placenta. {ECO:0000269|PubMed:15082789}. |
HEI-C CRISPR/Cas9 KO Plasmid (h) - sc-414064 from Santa Cruz Biotechnology
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HEI-C HDR Plasmid (h) - sc-414064-HDR from Santa Cruz Biotechnology
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HEI-C Double Nickase Plasmid (h) - sc-414064-NIC from Santa Cruz Biotechnology
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HEI-C Double Nickase Plasmid (h2) - sc-414064-NIC-2 from Santa Cruz Biotechnology
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HEI-C CRISPR Activation Plasmid (h) - sc-414064-ACT from Santa Cruz Biotechnology
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HEI-C CRISPR Activation Plasmid (h2) - sc-414064-ACT-2 from Santa Cruz Biotechnology
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HEI-C Lentiviral Activation Particles (h) - sc-414064-LAC from Santa Cruz Biotechnology
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HEI-C Lentiviral Activation Particles (h2) - sc-414064-LAC-2 from Santa Cruz Biotechnology
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HEI-C siRNA (h) - sc-75237 from Santa Cruz Biotechnology
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HEI-C shRNA Plasmid (h) - sc-75237-SH from Santa Cruz Biotechnology
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HEI-C shRNA (h) Lentiviral Particles - sc-75237-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU105161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9880 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9880 from Sigma-Aldrich
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HAUS1 siRNA (Human) - CRJ4429 from Cohesion Biosciences
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HAUS1 - MBS829312 from MyBioSource
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shRNA set against Human HAUS1 (NM_138443.3) - SHH310417 from Creative biogene
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Human HAUS1 siRNA - orb274930 from Biorbyt
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HAUS1 shRNA Plasmid (Human) - CHJ4429 from Cohesion Biosciences
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HAUS1 miRNA 3'UTR clone - MiUTR4H-TG04094 from Creative biogene
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