| Gene Symbol |
CIB1
|
| Entrez Gene |
10519
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| Alt Symbol |
CIB, CIBP, KIP1, PRKDCIP, SIP2-28
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium and integrin binding 1 (calmyrin)
|
| Other Description |
DNA-PK interaction protein|DNA-PKcs-interacting protein|DNA-dependent protein kinase interacting protein|SNK-interacting protein 2-28|calcium and integrin-binding protein 1
|
| Swissprots |
B5BU40 Q99828 Q99971 H6WJF3 O00693 O00735 Q96J54 Q6IB49
|
| Accessions |
BAA36281 EAX02087 EAX02088 EAX02089 EAX02090 Q99828 AA769426 AB451276 BAG70090 AB451406 BAG70220 BC000846 AAH00846 BG231771 BG759961 BI520476 CD622547 CR456955 CAG33236 DQ891196 ABM82122 DQ894379 ABM85305 HY070030 JQ246073 AEZ06077 U82226 AAC51106 U83236 AAB39758 U85611 AAB53387 XM_006720375 XP_006720438 NM_001277764 NP_001264693 NM_006384 NP_006375 NR_102427 NR_102428
|
| Function |
Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin- stimulated megakaryocytes preventing platelet aggregation. Up- regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stres
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| Subcellular Location |
Membrane; Lipid-anchor. Cell membrane, sarcolemma. Cell membrane. Apical cell membrane. Cell projection, ruffle membrane. Cell projection, filopodium tip. Cell projection, growth cone. Cell projection, lamellipodium. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart (By similarity). Colocalized with NBR1 to the perinuclear region. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with STMN2 in the cell body, neurites and growth cones of neurons. Colocalized wit
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| Tissue Specificity |
Detected in platelets and in cell lines of megakaryocytic and erythrocytic lineages. Both isoform 1 and isoform 2 are detected in various cancer cell lines, with isoform 2 being the predominant form (at protein level). Ubiquitously expressed. {ECO:0000269|PubMed:10477286, ECO:0000269|PubMed:11856312, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:9030514, ECO:0000269|PubMed:9372844}.
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