CIB1

Gene Symbol	CIB1
Entrez Gene	10519
Alt Symbol	CIB, CIBP, KIP1, PRKDCIP, SIP2-28
Species	Human
Gene Type	protein-coding
Description	calcium and integrin binding 1 (calmyrin)
Other Description	DNA-PK interaction protein|DNA-PKcs-interacting protein|DNA-dependent protein kinase interacting protein|SNK-interacting protein 2-28|calcium and integrin-binding protein 1
Swissprots	B5BU40 Q99828 Q99971 H6WJF3 O00693 O00735 Q96J54 Q6IB49
Accessions	BAA36281 EAX02087 EAX02088 EAX02089 EAX02090 Q99828 AA769426 AB451276 BAG70090 AB451406 BAG70220 BC000846 AAH00846 BG231771 BG759961 BI520476 CD622547 CR456955 CAG33236 DQ891196 ABM82122 DQ894379 ABM85305 HY070030 JQ246073 AEZ06077 U82226 AAC51106 U83236 AAB39758 U85611 AAB53387 XM_006720375 XP_006720438 NM_001277764 NP_001264693 NM_006384 NP_006375 NR_102427 NR_102428
Function	Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin- stimulated megakaryocytes preventing platelet aggregation. Up- regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stres
Subcellular Location	Membrane; Lipid-anchor. Cell membrane, sarcolemma. Cell membrane. Apical cell membrane. Cell projection, ruffle membrane. Cell projection, filopodium tip. Cell projection, growth cone. Cell projection, lamellipodium. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart (By similarity). Colocalized with NBR1 to the perinuclear region. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with STMN2 in the cell body, neurites and growth cones of neurons. Colocalized wit
Tissue Specificity	Detected in platelets and in cell lines of megakaryocytic and erythrocytic lineages. Both isoform 1 and isoform 2 are detected in various cancer cell lines, with isoform 2 being the predominant form (at protein level). Ubiquitously expressed. {ECO:0000269|PubMed:10477286, ECO:0000269|PubMed:11856312, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:9030514, ECO:0000269|PubMed:9372844}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CIB1 full length protein - ab40628 from Abcam Category Protein Prices $235.00 Sizes 50 µg Source E. coli

Human CIB1 full length protein - ab78759 from Abcam Category Protein Source E. coli Species Human

Human CIB1 peptide - ab43584 from Abcam Category Peptide

ABHD14B Antibody Blocking Peptide - LS-E10270 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ABHD14B Antibody Blocking Peptide - LS-E27882 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CIB1 / KIP Antibody Blocking Peptide - LS-E17477 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CIB1 Recombinant Protein - H00010519-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CIB1 Protein - NBC1-18394 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

CIB1 Protein (OPPA01707) - OPPA01707 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human CIB1 protein - orb80783 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

CIB1 peptide - orb218903 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

CIB1 protein (His tag) - 80R-1039 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

CIB1 Blocking Peptide - abx064234 from Abbexa Category Peptide Species Human, Rat, Monkey

CIB1 (1-191, His-tag) - AR09009PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CIB1 (1-191, His-tag) - AR09009PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

CIB1 - H00010519-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CIB1 - H00010519-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CIB1, 1-191 aa, Human, His-tagged, Recombinant, E.coli - 01-2288 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

CIB1 fusion protein - Ag2391 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CIB1 Human - PKPS-352 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Human

ABHD14B Human - ENPS-247 from NeoScientific Category Protein Prices $65.00, $169.00, $1,560.00 Sizes 1 µg, 5 µg, 50 µg Source E.coli. Species Human

Recombinant Human Calcium and Integrin Binding 1 Protein - BP002489-PKA-345 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 25 µg, 1 mg Source E. coli-derived. Species Human

CIB1, 1-191 aa, Recombinant Protein - GWB-P0238D from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Calcium and integrin-binding protein 1 - GWB-B785EB from Genway Biotech Category Protein Prices $185.00, $2,500.00 Sizes 50 µg, 1 mg

Recombinant Human Calcium and Integrin Binding 1 - GWB-8FF9E9 from Genway Biotech Category Protein Prices $75.00, $165.00, $3,230.00 Sizes 5 μg, 25 μg, 1000 μg Species Human

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