| Gene Symbol |
ROBO3
|
| Entrez Gene |
64221
|
| Alt Symbol |
HGPPS, HGPS, RBIG1, RIG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
roundabout, axon guidance receptor, homolog 3 (Drosophila)
|
| Other Description |
retinoblastoma inhibiting gene 1|roundabout homolog 3|roundabout-like protein 3
|
| Swissprots |
Q96MS0
|
| Accessions |
EAW67602 EAW67603 EAW67604 EAW67605 EAW67606 EAW67607 EAW67608 EAW67609 Q96MS0 AK024697 BAB14966 AK225076 AK291045 BAF83734 AK295475 BAG58402 AK298792 BAG60929 AY509035 AAS91662 BC008623 AAH08623 BC086878 BC113744 BC148593 AAI48594 N80769 XM_011542953 XP_011541255 NM_022370 NP_071765
|
| Function |
Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing. {ECO:0000250, ECO:0000269|PubMed:15105459}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Top Pathways |
Axon guidance
|