Gene Symbol | ROMO1 |
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Entrez Gene | 140823 |
Alt Symbol | C20orf52, MTGM, MTGMP, bA353C18.2 |
Species | Human |
Gene Type | protein-coding |
Description | reactive oxygen species modulator 1 |
Other Description | PCM19|ROS modulator 1|epididymis tissue protein Li 175|glyrichin|mitochondrial targeting GXXXG protein|mitochondrial targeting GxxxG motif protein|protein MGR2 homolog |
Swissprots | A7M872 Q3MHD5 Q5QP16 E1P5R9 E9KL28 P60602 |
Accessions | EAW76168 EAW76169 P60602 AK000548 AM397244 CAL37002 AM397245 CAL37003 AM397246 CAL37004 BC008488 AAH08488 BC105281 AAI05282 BM353595 GU727625 ADU87627 JF432445 ADZ15662 NM_080748 NP_542786 |
Function | Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}; Single-pass membrane protein {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}. |
Tissue Specificity | Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors. {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}. |
Romo1 CRISPR/Cas9 KO Plasmid (h) - sc-417144 from Santa Cruz Biotechnology
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Romo1 HDR Plasmid (h) - sc-417144-HDR from Santa Cruz Biotechnology
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Romo1 Double Nickase Plasmid (h) - sc-417144-NIC from Santa Cruz Biotechnology
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Romo1 Double Nickase Plasmid (h2) - sc-417144-NIC-2 from Santa Cruz Biotechnology
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Romo1 CRISPR Activation Plasmid (h) - sc-417144-ACT from Santa Cruz Biotechnology
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Romo1 CRISPR Activation Plasmid (h2) - sc-417144-ACT-2 from Santa Cruz Biotechnology
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Romo1 Lentiviral Activation Particles (h) - sc-417144-LAC from Santa Cruz Biotechnology
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Romo1 Lentiviral Activation Particles (h2) - sc-417144-LAC-2 from Santa Cruz Biotechnology
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Romo1 siRNA (h) - sc-76423 from Santa Cruz Biotechnology
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Romo1 shRNA Plasmid (h) - sc-76423-SH from Santa Cruz Biotechnology
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Romo1 shRNA (h) Lentiviral Particles - sc-76423-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU224321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18502 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18502 from Sigma-Aldrich
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ROMO1 siRNA (Human) - CRJ5326 from Cohesion Biosciences
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ROMO1 - MBS8230024 from MyBioSource
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shRNA set against Human ROMO1 (NM_080748.2) - SHH397684 from Creative biogene
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shRNA set against Human C20orf52(NM_080748.2) - SHR189636 from Creative biogene
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Romo1 CRISPR/Cas9 KO Plasmid (h2) - sc-417144-KO-2 from Santa Cruz Biotechnology
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Romo1 HDR Plasmid (h2) - sc-417144-HDR-2 from Santa Cruz Biotechnology
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ROMO1 shRNA Plasmid (Human) - CHJ5326 from Cohesion Biosciences
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ROMO1 miRNA 3'UTR clone - MiUTR1H-01326 from Creative biogene
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