| Gene Symbol |
Htr6
|
| Entrez Gene |
15565
|
| Alt Symbol |
5-HT6
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 6
|
| Other Description |
5-HT-6|5-hydroxytryptamine receptor 6|serotonin receptor 6
|
| Swissprots |
Q9R1C8
|
| Accessions |
EDL13293 Q9R1C8 AF134158 AAD46490 AK134977 BAE22367 BC116652 AAI16653 BC116653 AAI16654 XM_006538579 XP_006538642 XM_011250196 XP_011248498 NM_021358 NP_067333
|
| Function |
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (PubMed:25078650). Is an activator of TOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000269|PubMed:23027611, ECO:0000269|PubMed:25078650}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction
|