Gene Symbol | Htr6 |
---|---|
Entrez Gene | 15565 |
Alt Symbol | 5-HT6 |
Species | Mouse |
Gene Type | protein-coding |
Description | 5-hydroxytryptamine (serotonin) receptor 6 |
Other Description | 5-HT-6|5-hydroxytryptamine receptor 6|serotonin receptor 6 |
Swissprots | Q9R1C8 |
Accessions | EDL13293 Q9R1C8 AF134158 AAD46490 AK134977 BAE22367 BC116652 AAI16653 BC116653 AAI16654 XM_006538579 XP_006538642 XM_011250196 XP_011248498 NM_021358 NP_067333 |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (PubMed:25078650). Is an activator of TOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000269|PubMed:23027611, ECO:0000269|PubMed:25078650}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Top Pathways | Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction |
SR-6 CRISPR/Cas9 KO Plasmid (m) - sc-421000 from Santa Cruz Biotechnology
|
||||||||
SR-6 HDR Plasmid (m) - sc-421000-HDR from Santa Cruz Biotechnology
|
||||||||
SR-6 Double Nickase Plasmid (m) - sc-421000-NIC from Santa Cruz Biotechnology
|
||||||||
SR-6 Double Nickase Plasmid (m2) - sc-421000-NIC-2 from Santa Cruz Biotechnology
|
||||||||
SR-6 CRISPR Activation Plasmid (m) - sc-421000-ACT from Santa Cruz Biotechnology
|
||||||||
SR-6 CRISPR Activation Plasmid (m2) - sc-421000-ACT-2 from Santa Cruz Biotechnology
|
||||||||
SR-6 Lentiviral Activation Particles (m) - sc-421000-LAC from Santa Cruz Biotechnology
|
||||||||
SR-6 Lentiviral Activation Particles (m2) - sc-421000-LAC-2 from Santa Cruz Biotechnology
|
||||||||
SR-6 siRNA (m) - sc-42245 from Santa Cruz Biotechnology
|
||||||||
SR-6 shRNA Plasmid (m) - sc-42245-SH from Santa Cruz Biotechnology
|
||||||||
SR-6 shRNA (m) Lentiviral Particles - sc-42245-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU061571 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN33556 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33556 from Sigma-Aldrich
|
||||||||
HTR6 siRNA (Mouse) - CRM1968 from Cohesion Biosciences
|
||||||||
HTR6 - MBS8218017 from MyBioSource
|
||||||||
shRNA set against Mouse HTR6 (NM_021358.2) - SHH316021 from Creative biogene
|
||||||||
shRNA set against Mouse Htr6(NM_021358.2) - SHH136217 from Creative biogene
|
||||||||
Mouse HTR6 siRNA - orb281444 from Biorbyt
|
||||||||
HTR6 shRNA Plasmid (Mouse) - CHM1968 from Cohesion Biosciences
|
||||||||
HTR6 miRNA 3'UTR clone - MiUTR1M-05853 from Creative biogene
|