Gene Symbol | POU6F2 |
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Entrez Gene | 11281 |
Alt Symbol | RPF-1, WT5, WTSL |
Species | Human |
Gene Type | protein-coding |
Description | POU class 6 homeobox 2 |
Other Description | POU domain, class 6, transcription factor 2|Wilms tumor suppressor locus|retina-derived POU domain factor 1|retina-derived POU-domain factor-1 |
Swissprots | Q86UM6 P78425 C4AMB9 A4D1W2 P78424 Q9UDS7 Q75ME8 |
Accessions | AAB49727 AAC83404 AAP21873 AAS07475 EAL23992 EAW94116 EAW94117 P78424 AK309700 BC152915 AAI52916 DN991890 U91935 AAB49728 XM_011515113 XP_011513415 XM_011515114 XP_011513416 NM_001166018 NP_001159490 NM_007252 NP_009183 |
Function | Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Expressed only within the CNS, where its expression is restricted to the medical habenulla, to a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the retina. {ECO:0000269|PubMed:8601806}. |
POU6F2 CRISPR/Cas9 KO Plasmid (h) - sc-408828 from Santa Cruz Biotechnology
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POU6F2 HDR Plasmid (h) - sc-408828-HDR from Santa Cruz Biotechnology
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POU6F2 Double Nickase Plasmid (h) - sc-408828-NIC from Santa Cruz Biotechnology
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POU6F2 Double Nickase Plasmid (h2) - sc-408828-NIC-2 from Santa Cruz Biotechnology
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POU6F2 CRISPR Activation Plasmid (h) - sc-408828-ACT from Santa Cruz Biotechnology
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POU6F2 CRISPR Activation Plasmid (h2) - sc-408828-ACT-2 from Santa Cruz Biotechnology
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POU6F2 Lentiviral Activation Particles (h) - sc-408828-LAC from Santa Cruz Biotechnology
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POU6F2 Lentiviral Activation Particles (h2) - sc-408828-LAC-2 from Santa Cruz Biotechnology
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POU6F2 siRNA (h) - sc-89556 from Santa Cruz Biotechnology
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POU6F2 shRNA Plasmid (h) - sc-89556-SH from Santa Cruz Biotechnology
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POU6F2 shRNA (h) Lentiviral Particles - sc-89556-V from Santa Cruz Biotechnology
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POU6F2 RNAi - H00011281-R01 from Novus Biologicals
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MISSION® esiRNA - EHU099951 from Sigma-Aldrich
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MISSION® esiRNA - EHU093721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17190 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17190 from Sigma-Aldrich
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POU6F2 siRNA (Human) - CRH7736 from Cohesion Biosciences
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shRNA set against Human POU6F2 (NM_007252.3) - SHH380184 from Creative biogene
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Human POU6F2 siRNA - orb268238 from Biorbyt
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POU6F2 shRNA Plasmid (Human) - CHH7736 from Cohesion Biosciences
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POU6F2 miRNA 3'UTR clone - MiUTR3H-10379 from Creative biogene
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POU6F2 miRNA 3'UTR clone - MiUTR3H-10380 from Creative biogene
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