| Gene Symbol |
TRAK1
|
| Entrez Gene |
22906
|
| Alt Symbol |
MILT1, OIP106
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
trafficking protein, kinesin binding 1
|
| Other Description |
106 kDa O-GlcNAc transferase-interacting protein|O-linked N-acetylglucosamine transferase interacting protein 106|OGT(O-Glc-NAc transferase)-interacting protein 106 KDa|milton homolog 1|trafficking kinesin-binding protein 1
|
| Swissprots |
Q96B69 Q659B5 Q63HR0 Q9UPV9 J3KNT7 E9PDS2
|
| Accessions |
EAW64638 EAW64639 EAW64640 EAW64641 EAW64642 Q9UPV9 AA534633 AB028965 BAA82994 AK000754 AK023962 AK294221 BAH11704 AK295480 BAH12083 AK295848 BAH12201 AK316260 BAH14631 AL713787 CAH56394 AM392573 CAL37451 AM393596 CAL38473 AW157246 BC015922 AAH15922 BF527591 BG285410 BX647199 CAH56169 CD722736 DA193280 EU446989 ABZ92518 H05058 XM_005264956 XP_005265013 XM_005264957 XP_005265014 XM_005264958 XP_005265015 XM_005264959 XP_005265016 XM_005264960 XP_005265017 XM_005264962 XP_005265019 XM_005264963 XP_005265020 XM_006713028 XP_006713091 XM_006713029 XP_006713092 XM_006713030 XP_006713093 XM_006713031 XP_006713094 XM_011533487 XP_011531789 XM_011533488 XP_011531790 XM_011533489 XP_011531791 NM_001042646 NP_001036111 NM_001265608 NP_001252537 NM_001265609 NP_001252538 NM_001265610 NP_001252539 NM_014965 NP_055780
|
| Function |
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. {ECO:0000269|PubMed:18675823}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with MGARP at the mitochondria.
|
| Tissue Specificity |
High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined. {ECO:0000269|PubMed:18986759}.
|
![Western Blot: OIP106 Overexpression Lysate (Adult Normal) [NBL1-17251] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OIP106.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10554_OIP106%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17251-img0002.jpg)