PIEZO1

Gene Symbol	PIEZO1
Entrez Gene	9780
Alt Symbol	DHS, FAM38A, Mib
Species	Human
Gene Type	protein-coding
Description	piezo-type mechanosensitive ion channel component 1
Other Description	family with sequence similarity 38, member A|membrane protein induced by beta-amyloid treatment
Swissprots	A6NHT9 Q0KKZ9 A7E2B7 Q92508
Accessions	CAH05415 EAW66773 Q92508 AA825468 AB161230 BAF03565 AB384448 BAG10304 AK092007 AL582912 BC008073 AAH08073 BC016983 BC141877 BC150271 AAI50272 BE066337 D87071 BAA13240 KC602455 AGH27891 NM_001142864 NP_001136336
Function	Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship and are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensors that promote endothelial cell organization and alignment in the direction of blood flow. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. {ECO:0000250|UniProtKB:E2JF22, ECO:0000269|PubMed:20016066}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:20016066}; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane {ECO:0000250|UniProtKB:E2JF22}; Multi-pass membrane protein. Note=In erythrocytes, located in the plasma membrane. In response to shear stress there is an accumulation at the leading apical lamellipodia. {ECO:0000269|PubMed:25119035}.
Tissue Specificity	Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level). {ECO:0000269|PubMed:16854388, ECO:0000269|PubMed:22529292, ECO:0000269|PubMed:23479567}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PIEZO1 (G-14) - sc-164318 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PIEZO1 (N-15) - sc-164319 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-FAM38A antibody - ab186571 from Abcam Host Rabbit Clonality Polyclonal

Anti-FAM38A antibody - ab82336 from Abcam Prices $376.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FAM38A antibody - ab128245 from Abcam Prices $372.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody (Biotin) - LS-C180905 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody (C-Terminus) - LS-C153413 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody (DY650) - LS-C180906 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody (DY488) - LS-C180907 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody (HRP) - LS-C180908 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody (Biotin) - LS-C180910 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody (DY550) - LS-C180909 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody (DY650) - LS-C180911 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody (DY488) - LS-C180912 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody (DY550) - LS-C180913 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody - LS-C180176 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIEZO1 / FAM38A Antibody - LS-C180177 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PIEZO1 Antibody - NBP1-78537 from Novus Biologicals Prices $129.00, $349.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

PIEZO1 Antibody - NBP1-78446 from Novus Biologicals Prices $99.00, $299.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

PIEZO1 Antibody - NBP2-10504 from Novus Biologicals Prices $279.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PIEZO1 Antibody - NBP2-13758 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PIEZO1 Antibody [HRP] - NBP1-78446H from Novus Biologicals Prices $319.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PIEZO1 Antibody [DyLight 488] - NBP1-78446G from Novus Biologicals Prices $319.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PIEZO1 Antibody [DyLight 650] - NBP1-78446C from Novus Biologicals Prices $319.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PIEZO1 Antibody [Biotin] - NBP1-78446B from Novus Biologicals Prices $299.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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