| Gene Symbol |
PIEZO1
|
| Entrez Gene |
9780
|
| Alt Symbol |
DHS, FAM38A, Mib
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
piezo-type mechanosensitive ion channel component 1
|
| Other Description |
family with sequence similarity 38, member A|membrane protein induced by beta-amyloid treatment
|
| Swissprots |
A6NHT9 Q0KKZ9 A7E2B7 Q92508
|
| Accessions |
CAH05415 EAW66773 Q92508 AA825468 AB161230 BAF03565 AB384448 BAG10304 AK092007 AL582912 BC008073 AAH08073 BC016983 BC141877 BC150271 AAI50272 BE066337 D87071 BAA13240 KC602455 AGH27891 NM_001142864 NP_001136336
|
| Function |
Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship and are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensors that promote endothelial cell organization and alignment in the direction of blood flow. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. {ECO:0000250|UniProtKB:E2JF22, ECO:0000269|PubMed:20016066}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:20016066}; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane {ECO:0000250|UniProtKB:E2JF22}; Multi-pass membrane protein. Note=In erythrocytes, located in the plasma membrane. In response to shear stress there is an accumulation at the leading apical lamellipodia. {ECO:0000269|PubMed:25119035}.
|
| Tissue Specificity |
Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level). {ECO:0000269|PubMed:16854388, ECO:0000269|PubMed:22529292, ECO:0000269|PubMed:23479567}.
|