Gene Symbol | LTB4R2 |
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Entrez Gene | 56413 |
Alt Symbol | BLT2, BLTR2, JULF2, KPG_004, LTB4-R 2, LTB4-R2, NOP9 |
Species | Human |
Gene Type | protein-coding |
Description | leukotriene B4 receptor 2 |
Other Description | LTB4 receptor JULF2|leukotriene B4 receptor BLT2|seven transmembrane receptor BLTR2 |
Swissprots | Q5KU28 Q9NPE5 Q9NPC1 |
Accessions | AAP23200 BAB00610 BAB89317 CAB96134 EAW66030 Q9NPC1 AB029892 BAA99553 AB032558 BAD83590 AB044402 BAA99539 AF277230 AAF81261 AF308571 AAG40857 AK304169 BAG65054 BC038437 BC119674 AAI19675 BC127643 AAI27644 BC172240 AAI72240 BC172548 AAI72548 DC408599 NM_001164693 NM_001164692 NP_001158164 NM_019839 NP_062813 |
Function | Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Widely expressed. |
Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
LTB4R2 CRISPR/Cas9 KO Plasmid (h) - sc-405387 from Santa Cruz Biotechnology
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LTB4R2 HDR Plasmid (h) - sc-405387-HDR from Santa Cruz Biotechnology
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LTB4R2 Double Nickase Plasmid (h) - sc-405387-NIC from Santa Cruz Biotechnology
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LTB4R2 Double Nickase Plasmid (h2) - sc-405387-NIC-2 from Santa Cruz Biotechnology
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LTB4R2 CRISPR Activation Plasmid (h) - sc-405387-ACT from Santa Cruz Biotechnology
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LTB4R2 CRISPR Activation Plasmid (h2) - sc-405387-ACT-2 from Santa Cruz Biotechnology
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LTB4R2 Lentiviral Activation Particles (h) - sc-405387-LAC from Santa Cruz Biotechnology
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LTB4R2 Lentiviral Activation Particles (h2) - sc-405387-LAC-2 from Santa Cruz Biotechnology
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LTB4R2 siRNA (h2) - sc-270417 from Santa Cruz Biotechnology
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LTB4R2 shRNA Plasmid (h2) - sc-270417-SH from Santa Cruz Biotechnology
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LTB4R2 shRNA (h2) Lentiviral Particles - sc-270417-V from Santa Cruz Biotechnology
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Leukotriene B4 Receptor 2 RNAi - H00056413-R02 from Novus Biologicals
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NOP9 RNAi - H00161424-R01 from Novus Biologicals
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MISSION® esiRNA - EHU218861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12814 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12814 from Sigma-Aldrich
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LTB4R2 siRNA (Human) - CRJ1140 from Cohesion Biosciences
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shRNA set against Human LTB4R2 (NM_019839.4) - SHH335451 from Creative biogene
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Human LTB4-R2 siRNA - orb271641 from Biorbyt
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LTB4R2 shRNA Plasmid (Human) - CHJ1140 from Cohesion Biosciences
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LTB4R2 miRNA 3'UTR clone - MiUTR3H-07939 from Creative biogene
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