CBL

Gene Symbol CBL
Entrez Gene 867
Alt Symbol C-CBL, CBL2, FRA11B, NSLL, RNF55
Species Human
Gene Type protein-coding
Description Cbl proto-oncogene, E3 ubiquitin protein ligase
Other Description Cas-Br-M (murine) ecotropic retroviral transforming sequence|E3 ubiquitin-protein ligase CBL|RING finger protein 55|casitas B-lineage lymphoma proto-oncogene|fragile site, folic acid type, rare, fra(11)(q23.3)|oncogene CBL2|proto-oncogene c-Cbl|signal transduction protein CBL
Swissprots P22681 A3KMP8
Accessions CAA57977 EAW67476 P22681 AA806454 AK092300 AL832396 BC132733 AAI32734 BC136463 AAI36464 BG722940 BX648139 DB457271 X57110 CAA40393 X69207 XM_011543057 XP_011541359 NM_005188 NP_005179
Function Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be
Subcellular Location Cytoplasm. Cell membrane. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Top Pathways Proteoglycans in cancer, Ubiquitin mediated proteolysis, Bacterial invasion of epithelial cells, Endocytosis, ErbB signaling pathway

E3 ubiquitin-protein ligase CBL (CBL), Human, ELISA Kit - CSB-EL004578HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

CBL (Human) IP-WB Antibody Pair - H00000867-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

CBL (Human) IP-WB Antibody Pair - H00000867-PW2 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

CBL (Human) Matched Antibody Pair - H00000867-AP11 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

CBL (Human) Matched Antibody Pair - H00000867-AP21 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Cas-Br-M (murine) ecotropic retroviral transforming sequence, ELISA Kit - MBS943423 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 6.25 pg/ml.
Range 25 pg/ml-1600 pg/ml.

CBL Colorimetric Cell-Based ELISA Kit - CB5110 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

CBL (Phospho-Tyr774) Colorimetric Cell-Based ELISA Kit - CBP1145 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

CBL (Phospho-Tyr700) Colorimetric Cell-Based ELISA Kit - CBP1146 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

CBL (Phospho-Tyr674) Colorimetric Cell-Based ELISA Kit - CBP1147 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Human E3 ubiquitin-protein ligase CBL(CBL) ELISA kit - CSB-EL004578HU from Cusabio

Category ELISA Kit
Sensitivity 6.25 pg/ml
Range 25 pg/ml-1600 pg/ml

CBL ELISA Kit - DEIA-XYA1004 from Creative Diagnostics

Category ELISA Kit

CBL (Phospho-Tyr674) ELISA Kit - DEIA-XYA892 from Creative Diagnostics

Category ELISA Kit

CBL (Phospho-Tyr700) ELISA Kit - DEIA-XYA893 from Creative Diagnostics

Category ELISA Kit

CBL (Phospho-Tyr774) ELISA Kit - DEIA-XYA894 from Creative Diagnostics

Category ELISA Kit

Human CBL ELISA Kit - E006788 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human CBL is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean

anti-c-Cbl antibody - ARG63177 from Arigo Biolaboratories

Category ELISA Kit

CBL Colorimetric Cell-Based ELISA Kit - EKA50098 from Biomatik

Category ELISA Kit
Prices $399.00
Sizes 96 tests
Sensitivity At least 5000 cells/well
Range Qualitative
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